Zefikam 8 mg 20 tablets

Tradename:

Zefikam

Composition:

Each tablet contains:

Lornoxicam 8 mg

Properties:

NSAIDs, belongs to the class of oxicams. It has a pronounced anti-inflammatory and analgesic effect, and also has an antipyretic and antiplatelet effect.

The mechanism of action is associated with the suppression of inflammatory factors; inhibition of prostaglandin synthesis due to inhibition of COX1 and COX2, which leads to disruption of the metabolism of arachidonic acid and inhibition of prostaglandin synthesis both in the focus of inflammation and in healthy tissues. Suppresses the exudative and proliferative phases of inflammation.

Indications:

Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, articular syndrome with exacerbation of gout, bursitis, tendovaginitis.

Moderate and severe pain syndrome (including arthralgia, myalgia, neuralgia, lumbago, sciatica, migraine, toothache and headache, algomenorrhea, pain in trauma, burns. Febrile syndrome (with colds and infectious diseases).

Method of administration and dosage:

When taken orally – 4 mg 2-3 times / day or 8 mg 2 times / day, intravenous or intramuscularly, the initial dose is 8-16 mg. With insufficient analgesic effect at a dose of 8 mg, you can re-enter another 8 mg.

Maximum daily doses: for oral administration – 16 mg; with concomitant diseases of the gastrointestinal tract, impaired renal or liver function, elderly patients (over 65 years old), with a body weight of less than 50 kg, as well as after extensive surgery – 12 mg in 3 divided doses.

Contraindications:

Acute bleeding from the gastrointestinal tract, gastric ulcer and duodenal ulcer in the acute phase, ulcerative colitis in the acute phase, bronchial asthma, severe chronic heart failure, hypovolemia, blood clotting disorders (including hemophilia, hemorrhagic diathesis, thrombocytopenia), severe hepatic and / or renal failure, deficiency of glucose-6-phosphate dehydrogenase, cerebral hemorrhage (including suspicion), pregnancy, lactation, children and adolescents under 18 years of age, hypersensitivity to lornoxicam, acetylsalicylic acid or other NSAIDs.

Precautionary measures:

Use with caution in case of erosive and ulcerative lesions and bleeding from the gastrointestinal tract (in history), moderate renal failure, conditions after surgery, in elderly patients (over 65 years old), in patients weighing less than 50 kg.

Lornoxicam should be used only after a careful assessment of the expected benefits of therapy and the possible risk in the following cases: a slight degree of impaired renal function (serum creatinine level 150-300 μmol / l); heart failure and other conditions, accompanied by a decrease in BCC and renal blood flow; liver dysfunction; arterial hypertension and conditions accompanied by fluid retention, edema; patients who have undergone extensive surgery.

In patients with impaired renal function during the treatment period, regular monitoring of renal function is necessary.

Side effects:

From the digestive system: abdominal pain, diarrhea, dyspepsia, nausea, vomiting, heartburn, diarrhea; rarely – flatulence, dry mouth, gastritis, esophagitis, erosive and ulcerative lesions of the mucous membrane of the stomach and intestines, bleeding from the gastrointestinal tract (including rectal), liver dysfunction.

From the side of the central nervous system: rarely – dizziness, headache, drowsiness, a state of agitation, sleep disturbances, depression, tremor, aseptic meningitis.

From the hematopoietic system: rarely – leukopenia, thrombocytopenia, agranulocytosis.

From the side of the blood coagulation system: with prolonged use in high doses – bleeding (gastrointestinal, gingival, uterine, nasal, rectal, hemorrhoidal), anemia.

From the side of metabolism: rarely – increased sweating, chills, changes in body weight.

From the side of the cardiovascular system: rarely – arterial hypertension, tachycardia, development or worsening of heart failure.

From the urinary system: rarely – dysuria, decreased glomerular filtration, interstitial nephritis, glomerulonephritis, papillary necrosis, nephrotic syndrome, peripheral edema, acute renal failure.

Allergic reactions: skin rash, itching, urticaria, angioedema, bronchospasm.

Storage method:

At a temperature not higher than 30 degrees.

Package:

The cardboard box holds a blister of 10 tablets.