Tradename:

Albendazole

Composition:

Each tablet contains:

Albentazole 400 mg

Auxiliary components:

lactose monohydrate, corn starch, polyvinylpyrrolidone K 30 (PVP 1<30), sodium lauryl sulfate, sodium saccharin, iron (Ill) oxide red (E 172), sodium starch glycolate type A (Explotab), microcrystalline cellulose PH 102, magnesium stearate

Properties:

Albendazole@ is a broad-spectrum antiprotozoal and anthelmintic drug, a benzimidazole carbamate derivative.

Albendazole@ disrupts the processes of glucose transport, inhibits the polymerization of beta-tubulin, causes disruption of the function of the microtubular apparatus in the helminth’s body, which leads to its death a excretion from the human body.

The drug is active against intestinal parasites that cause Larva Migrans cutaneous syndrome (wandering larva syndrome)

• Nematodae (roundworms): Ascaris lumbricoides (roundworm), Trichocephalus trichiuris (whipworm), Enterobius vermicularis (pinworm), Ancylostoma duodenale

(hookworm), Necator americanus,

Strongyloides stercoralis, Trichinella spiralis;

• Cestoidea (tapeworms): Hymenolepsis nana (dwarf tapeworm), Taenia saginata (bovine tapeworm);
• Pretosae (protozoa): Giardia lamblia (intestinal or duodenal).

Albendazole@ is active against tissue parasites, Echinococcus granulosus and

Echinococcus multilocularis causing cystic and alveolar echinococcosis. Albendazole@ is effective in the treatment of hepaticolesis caused by Capilaria philippinensis. Most of the drugs used to treat ascariasis are effective against the intestinal stage of this helminthiasis.

Albendazole@ is effective at all stages of the development of roundworm, trichinella. The efficiency is 95-100%.

Indications:

• enterobiasis
• ankylostomiasis and necatorosis

hymenolepiasis

• teniasis
• strongyloidosis
• ascariasis
• trichocephalosis
• Larva Migrans skin syndrome
• giardiasis
• cystic echinococcosis (hepatic, alveolar, peritoneal)
• trichinosis

Method of administration and dosage:

The drug is taken orally, during or after a meal, the tablets are not chewed, washed down with water. The use of laxatives and a special diet are not required. It is recommended that all family members be treated simultaneously. The dose is set individually, depending on the type of helminth and the patient’s body weight. For patients who are unable to swallow the pill whole, it is recommended to crush it and drink it with a little liquid.

The dosage regimen is set individually, depending on age, body weight, and the severity of the infection.

Intestinal infections and Larva Migrans skin syndrome:

400 mg 1 time/ day (1 tablet) for 3 days.

With hymenolepiasis, a second course of treatment is recommended, lasting from 10 days to 21 days.

Systemic helminth infections:

The dose for patients with a body weight of more than 60 kg is 400 mg (1 tablet) 2 times a day.

With a weight less than 60 kg, the drug is prescribed at the rate of 15 mg / kg / day. This dose should be divided into 2 doses.

Contraindications:

hypersensitivity to albendazole and other components of the drug

• pathology of the retina
• galactose intolerance, Lapp lactase deficiency, glucose / galactose malabsorption
• pregnancy and lactation.

Precautionary measures:

Albendazole@ can cause bone marrow suppression and blood tests should be monitored at the beginning and every two weeks of every 28-day cycle. Patients with liver disease, including hepatic echinococcosis, have a more pronounced tendency to suppress the bone marrow, leading to pancytopenia, aplastic anemia, agranulocytosis and leukopenia, which requires careful monitoring of the blood picture. With a clinically significant decrease in the level of blood cells, Albendazole@ should be canceled. In the course of short courses of treatment, it is necessary to control peripheral blood (once every 5—7 days) and aminotransferases at the same time.

Taking the drug Albendazole@ for the treatment of systemic helminth infections can cause seizures, increased intracranial pressure and focal symptoms associated with the death of parasites. In this case, it is necessary to immediately begin treatment with steroids and anticonvulsants. In case of eye damage, an examination of the retina is necessary befo starting treatment.

Side effects :

Often

• headache
• a slight or moderate increase in the level of liver enzymes

Often

dizziness

• abdominal pain, nausea, vomiting and diarrhea (in the treatment of echinococcosis)
• reversible alopecia (thinning and moderate hair loss)
• fever

Sometimes

• hypersensitivity reactions, including rash, itching and hives
• leukopenia
• hepatitis

Very rarely

• pancytopenia, aplastic anemia, agranulocytosis (patients with liver pathology, including hepatic echinococcosis, are more prone to suppression of the bone marrow function)
• erythema multiforme, Stevens-Johnson syndrome

Storage method:

In a dry place at a temperature not exceeding 30 degrees.

Packaging:

The cardboard box holds 1 blister of 6 tablets.