Tradename:

Protopan

Composition:

Each capsule contains:

Esomeprazole – 40mg.

Properties:

Esomeprazole, a proton pump inhibitor, is the S-isomer of omeprazole and reduces the secretion of hydrochloric acid in the stomach.

Indications:

Treatment of gastroesophageal reflux disease (GERD); short-term treatment (from 4 to 8 weeks) of erosive esophagitis, symptoms of GERD (heartburn, etc.). Supportive therapy for symptoms and healing of erosive esophagitis for no more than 6 months. Treatment of patients with Helicobacter pylori infection and duodenal ulcer. Zollinger-Ellison Syndrome. Patients requiring long-term NSAID therapy healing of stomach ulcers, prevention of gastric and duodenal ulcers associated with NSAI therapy.

Mode of application:

Adults and adolescents from 12 years of age, capsules should be swallowed whole with 1/2 glass of water, with food or on an empty stomach. For patients who are unable to swallow, capsules can be opened and poured into water. Gastroesophageal reflux disease (GERD) – treatment: 40 mg once a day for 4 weeks. To prevent relapse, symptomatic treatment of GERD is 20 mg once a day. Maintenance therapy: 20 mg once a day.

For adults, in combination with antibacterial drugs for the destruction of Helicobacter pylori, prevention of recurrence of peptic ulcers in patients with peptic ulcer diseases: 20 mg of esomeprazole with 1 g of amoxicillin and 500 mg of clarithromycin, 2 times a day, for 7 days. Healing of stomach ulcers associated with NSAID therapy: 20 mg once a day. The duration of treatment is 4-8 weeks. Prevention of gastric ulcer and duodenal ulcer associated with NSAID therapy: 20 mg once a day.

Zollinger Ellison Syndrome: Initial dose of 40 mg 2 times a day. Then the dose should be selected individually and treatment should continued as long as it is clinically indicated. Most patients can be controlled at doses of 80-

160 mg per day, in 2 divided doses.

For patients with severe hepatic impairment:

the maximum dose of esomeprazole is 20 mg.

Contraindications:

Children under 12 years old; hypersensitivity to esomeprazole or any other components of the drug; pregnancy and lactation.

Precautions:

Proton pump inhibitor (PPI) therapy may be associated with an increased risk of hip, wrist, or spinal fractures associated with osteoporosis with long-term high-dose therapy.

Side effects:

Headache, dizziness, diarrhea, flatulence, abdominal pain, nausea, constipation, skin reactions (hot flashes, itching), burning / tingling / numbness, drowsiness, dry mouth, swelling of the hands and feet, increased liver enzymes, blurred vision, depression, irritabil’ confusion, taste disturbances, hair loss, pai joints and muscles, excessive sweating.

Storage:

Store at a temperature not exceeding 30C in its original packaging, in a dry place out of the reach of children.

Packaging:

The cardboard box contains 2 blisters of 7 capsules each, paper instructions.