Primperan 10 mg 10 tablets

Tradename:

Primperan

Primperan

Composition:

Each tablet contains:

Metoclopramide hydrochloride 10.00 mg

Auxiliary components:

Lactose monohydrate, microcrystalline cellulose, starch, magnesium stearate.

Properties:

Antiemetic, helps to reduce nausea, hiccups; stimulates gastrointestinal motility. The antiemetic effect is due to the blockade of dopamine D2 receptors and an increase in the threshold of the trigger zone chemoreceptors, is a blocker of serotonin receptors. It is believed that metoclopramide inhibits dopamineinduced relaxation of gastric smooth muscl thereby enhancing the cholinergic response gastrointestinal smooth muscles. Helps to accelerate gastric emptying by preventing

relaxation of the stomach body and increasing the activity of the antrum and upper small intestine. Reduces the reflux of the contents into the esophagus by increasing the pressure of the esophageal sphincter at rest and increases the clearance of acid from the esophagus due to an increase in the amplitude of its peristaltic contractions.

Metoclopramide stimulates the secretion of prolactin and causes a transient increase in circulating aldosterone levels, which may be accompanied by short-term fluid retention.

Indications:

Vomiting, nausea, hiccups of various origins. Atony and hypotension of the stomach and intestines (including postoperative); biliary dyskinesia; reflux esophagitis; flatulence; as part of the complex therapy of exacerbations of gastric ulcer and duodenal ulcer; acceleration of peristalsis during radiopaque studies of the gastrointestinal tract.

Method of administration and dosage:

For adults inside – 10 mg 1-3 times / day. vomiting, severe nausea, metoclopramide is administered intramuscularly or intravenously

at a dose of 10 mg.

Maximum doses:

when taken orally – 30 mg per day;

The course of treatment is up to 5 days.

The average single dose for children over 6 years of age is 5 mg 1-3 times / day by mouth or parenterally. For children under 6 years of age, the daily dose for parenteral administration is 0.5-1 mg / kg, the frequency of administration is 1-3 times / day.

Contraindications:

Bleeding from the gastrointestinal tract, mechanical intestinal obstruction, perforation of the stomach or intestines, pheochromocytoma, extrapyramidal disorders, epilepsy, prolactin-dependent tumors, glaucoma, pregnancy, lactation, simultaneous use of anticholinergic drugs, hypersensitivity to metoclopramide.

Precautions:

Use with caution in patients with bronchial asthma, arterial hypertension, impaired liver and / or kidney function, and Parkinson’s disease.

It should be used with extreme caution in children, especially young children. they have a significantly higher risk of dyskinetic syndrome. In some cases, metoclopramide can be effective for vomiting caused by taking cytostatics.

When used in elderly patients, it should be borne in mind that with prolonged use of metoclopramide in high or medium doses, the most common side effects are extrapyramidal disorders, especially parkinsonism and tardive dyskinesia.

Against the background of the use of metoclopramide, distortions of the data of laboratory indicators of liver function and determination of the concentration of aldosterone and prolactin in blood plasma are possible.

Influence on the ability to drive vehicles and use mechanisms

During the period of treatment, you should avoid potentially hazardous activities that require increased attention, rapid psychomotor reactions.

Side effects:

From the digestive system: at the beginning of treatment, constipation, diarrhea are possible; rarely dry mouth.

From the side of the central nervous system: at the beginning of treatment, a feeling of fatigue, drowsiness, dizziness, headache, depression, akathisia are possible. It is possible that extrapyramidal symptoms occur in children and young people (even after a single use of metoclopramide): spasm of the facial muscles, hyperkinesis, spastic torticollis (usually disappear immediately after stopping metoclopramide). With prolonged use, more often in elderly patients, parkinsonism and dyskinesia are possible.

From the hematopoietic system: at the beginning of treatment, agranulocytosis is possible.

From the endocrine system: rarely, with prolonged use in high doses – galactorrhea, gynecomastia, menstrual irregularities.

Allergic reactions: rarely – skin rash.

Storage method:

At a temperature not higher than 30 degrees. In a dry place.

Packaging:

The cardboard box holds 20, 40 or 150 tablets.