Pentasa Xtend 2 g 60 sachets

Pentasa Xtend 2 g 60 sachets

Composition:

Each sachet contains Mesalazine (Mesalamine) 2 g.

Product Description:

Pentasa Xtend is a prolonged-release oral formulation of mesalazine designed to deliver the active substance throughout the gastrointestinal tract.
Granules are supplied in individual sachets for once- or twice-daily dosing.
Indicated for inflammatory bowel disease management.

Properties of the Product:

Mesalazine is an anti-inflammatory agent acting locally on the colonic mucosa.
It inhibits cyclooxygenase and reduces prostaglandin production.
Prolonged-release granules ensure continuous delivery along the intestine.
Supports mucosal healing and reduces inflammatory activity in ulcerative colitis.

Indications for Use:

Treatment of mild to moderate ulcerative colitis.
Maintenance of remission in ulcerative colitis.
May be used in other inflammatory bowel conditions as directed by a gastroenterologist.

Method of Administration and Dosage:

Administer orally; granules may be taken directly from the sachet or mixed with soft food.
Do not chew; swallow granules whole.
Typical adult dosing: 2 g to 4 g daily in divided or single doses, depending on disease severity.
Dosing must follow physician instructions.
Drink adequate fluids.

Contraindications:

Hypersensitivity to mesalazine, salicylates, or any excipients.
Severe renal impairment.
Severe hepatic impairment.
Known gastric or duodenal ulcers unless supervised by a specialist.

Precautions:

Monitor renal function before and during treatment.
Use with caution in patients with asthma.
Avoid concomitant nephrotoxic drugs when possible.
Discontinue if acute intolerance syndrome occurs (cramping, abdominal pain, fever, headache, rash).
Regular blood tests may be required.

Adverse Reactions / Side Effects:

Common: abdominal pain, diarrhea, nausea, headache.
Uncommon: rash, dizziness, fever.
Rare: pancreatitis, nephritis, blood dyscrasias.
Very rare: myocarditis, pericarditis.
Stop treatment and seek medical advice if severe reactions occur.

Pregnancy and Lactation:

Use only if clearly needed and under medical supervision.
Mesalazine crosses the placenta and is excreted in breast milk in small amounts.
Monitor infants for diarrhea if used during breastfeeding.

Storage Conditions:

Store below 25°C.
Keep sachets in the original packaging to protect from moisture.
Keep out of reach of children.

Packaging:

Carton box containing 60 sachets of prolonged-release granules for oral use.