Healsec 20 mg 14 capsules

Healsec 20 mg 14 capsules

Composition: Each capsule contains:

Omeprazole 20 mg

Auxiliary components:

Croscarmellose sodium, Lactose monohydrate, Povidone, Magnesium stearate, Methacrylic acid polymer type C, Talc

Description:

Healsec is an H⁺-K⁺-ATPase inhibitor. It inhibits the activity of H⁺-K⁺-ATPase in the parietal cells of the stomach, blocking the final stage of hydrochloric acid secretion. This results in decreased basal and stimulated acid secretion, regardless of the stimulus nature. By reducing acid secretion, Healsec alleviates or normalizes acid effects on the esophagus in patients with reflux esophagitis.

Omeprazole also exhibits bactericidal activity against Helicobacter pylori. Combining omeprazole with antibiotics ensures faster symptom relief, promotes mucosal healing, achieves long-term remission, and reduces the risk of gastrointestinal bleeding.

Indications:

-Peptic ulcers of the stomach and duodenum in the acute phase (including those associated with H. pylori).

-Reflux esophagitis.

-Zollinger-Ellison syndrome.

-Erosive and ulcerative lesions of the stomach and duodenum due to NSAID intake.

Dosage and Method of administration:

Take orally with water (capsule contents must not be chewed), 30 minutes before meals.

Peptic ulcers (not associated with H. pylori):

Resistant cases: 40 mg/day.

Duodenal ulcer: 2 weeks (extendable to 4 weeks if necessary).

Gastric ulcer: 4–8 weeks.

Gastroesophageal reflux disease (GERD):

Dose depends on esophagitis severity (up to 80 mg/day).

Standard: 40 mg (1–2 capsules daily) for 4–8 weeks.

Maintenance therapy at the lowest effective dose (as determined by a doctor).

Helicobacter pylori eradication:

As part of combination therapy:

Triple regimen (first-line):

Healsec 40 mg once daily + clarithromycin 500 mg twice daily + amoxicillin 1000 mg twice daily (10–14 days).

For increased efficacy, Healsec 40 mg can be taken twice daily.

Quadruple regimen (second-line):

Used when triple therapy fails or with penicillin intolerance:

Healsec 40 mg once daily.

Bismuth tripotassium dicitrate 120 mg 4 times daily.

Tetracycline 500 mg 4 times daily.

Metronidazole 500 mg 4 times daily (10 days).

Alternative therapies:

Based on individual H. pylori sensitivity to antibiotics.

Hypersecretory conditions (e.g., Zollinger-Ellison syndrome):

Initial dose: 40 mg once daily, adjustable up to 80–120 mg/day (divided into 2–3 doses).

NSAID-associated gastropathy:

40 mg once daily for 4–8 weeks.

Mendelsohn’s syndrome prevention:

40 mg once before general anesthesia.

Pediatric use:

Children >2 years (weight >20 kg): GERD – 0.7–3.3 mg/kg/day for 4–8 weeks.

Children >4 years (weight >20 kg): H. pylori eradication – 1–2 mg/kg/day with antibiotics.

Special Cases:

Liver dysfunction:

Bioavailability and clearance increase in impaired liver function.

Dose should not exceed 20 mg/day.

40 mg is contraindicated.

Elderly patients: Slower metabolism, but no dose adjustment required.

Contraindications:

-Hypersensitivity to omeprazole, substituted benzimidazoles, or other components.

-Simultaneous use with nelfinavir, atazanavir, erlotinib, or posaconazole.

Precautions:

Consult your doctor in the following cases:

-Previously diagnosed gastric ulcers.

-Severe liver disease or liver failure.

-Renal failure or jaundice.

-Prior gastrointestinal surgery.

-Alarm symptoms: significant weight loss, vomiting (with or without blood), melena, or difficulty swallowing.

-Persistent symptoms (e.g., heartburn lasting over 4 weeks).

-Concurrent use of clopidogrel, digoxin, warfarin, or other drugs affecting absorption or metabolism.

Patients at risk of osteoporosis-related fractures should undergo clinical monitoring.

Side Effects:

-Digestive system: Diarrhea, constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disturbances, stomatitis, increased liver enzymes, hepatitis (rare).

-Nervous system: Headache, dizziness, drowsiness, insomnia, agitation, paresthesia, depression, hallucinations.

-Musculoskeletal system: Muscle weakness, myalgia, arthralgia.

-Hematopoietic system: Rare leukopenia, thrombocytopenia, or pancytopenia.

-Skin: Rash, itching, photosensitivity, alopecia (rare).

-Allergic reactions: Urticaria, angioedema, anaphylaxis (rare).

-Others: Blurred vision, peripheral edema, gynecomastia, fever.

Storage Method:

Store at a room temperature

Avoid contact with direct sunlight and source of heat

Packaging:

Cardboard box containing a plastic jar with 7 or 14 capsules.