Glucovance 500/5mg 30 tablets

Glucovance

Compound:

Each tablet contains:

Glibenclamide 5 mg

Metformin hydrochloride 500mg

Auxiliary components:

Microcrystalline cellulose, croscarmellose sodium, povidone K 30, magnesium stearate.

Properties:

The combined oral hypoglycemic drug contains a second generation sulfonylurea derivative and a biguanide. It has pancreatic and extrapancreatic effects.

Glibenclamide is a second generation sulfonylurea derivative. Stimulates insulin secretion by lowering the threshold of glucose irritation of pancreatic β-cells, increases insulin sensitivity and the degree of its binding to target cells, increases insulin release, enhances the effect of insulin on glucose uptake by muscles and liver, and inhibits lipolysis in adipose tissue. Acts in stage II of insulin secretion.

Metformin belongs to the group of biguanides. Stimulates the peripheral sensitivity of tissues to the action of insulin (increases the binding of insulin to receptors, enhances the effects of insulin at the post-receptor level), reduces the absorption of glucose in the intestine, suppresses gluconeogenesis and has a beneficial effect on lipid metabolism, helps to reduce excess body weight in patients with diabetes mellitus, and also has a fibrinolytic effect due to the suppression of a tissue-type plasminogen activator inhibitor.

Indications:

Type 2 diabetes mellitus with the ineffectiveness of diet therapy and previous therapy with sulfonylurea derivatives or biguanides, as well as other oral hypoglycemic agents.

Dosage and administration:

The drug is taken orally during meals.

The dosage regimen and duration of treatment are set by the attending physician, depending on the state of carbohydrate metabolism and the concentration of glucose in the blood.

The initial dose is, as a rule, 1-3 tablets / day, with further gradual selection of an effective dose until a stable normalization of blood glucose concentration is achieved.

The maximum daily dose of the drug is 3 tab.

Contraindications:

-diabetes mellitus type 1;

– gestational diabetes mellitus;

-diabetic ketoacidosis, diabetic precoma, diabetic coma;

– lactic acidosis (including history);

– conditions accompanied by impaired absorption of food and the development of hypoglycemia;

– Impaired liver function;

-infectious diseases;

-hypoxic conditions (cardiac or respiratory failure, recent myocardial infarction, shock, severe respiratory disease);

– a period of 48 hours before and 48 hours after radioisotope or X-ray studies with the introduction of an iodine-containing contrast agent;

– the period within 48 hours before and 48 hours after the surgical intervention;

– dystrophic diseases (myotonic dystrophy, lipodystrophy);

– leukopenia;

– porphyria;

chronic alcoholism, acute alcohol intoxication.

Precautionary measures:

It is not recommended to use the drug in patients over 60 years of age who perform heavy physical work, which is associated with an increased risk of developing lactic acidosis in them.

The drug should be used with caution in febrile syndrome; thyroid diseases (with impaired function); hypofunction of the anterior pituitary and / or adrenal cortex.

During treatment, patients should strictly follow the doctor’s recommendations regarding the dosage and method of using the drug, as well as diet, exercise regimen and self-monitoring of blood glucose levels.

Side effects:

From the digestive system: rarely – nausea, vomiting, loss of appetite, abdominal pain, diarrhea, metallic taste in the mouth;

From the hemopoietic system: rarely – leukopenia, thrombocytopenia, erythrocytopenia;

From the side of the central nervous system: infrequently – headache.

On the part of the skin: rarely – urticaria, erythema, pruritus, photosensitivity.

From the side of metabolism: rarely – hypoglycemia; very rarely – lactic acidosis.

Storage method:

Store at a temperature not exceeding 30 degrees.

Package:

The cardboard box contains 2 blisters of 15 tablets, paper instructions.