Trade name:

Diamicron MR

Composition:

Each tablet contains:

Glyclaside 60 mg

Auxiliary components:

Calcium hydrogen phosphate dihydrate, maltodextrin, hypromelose, magnesium stearate, microcrystalline cellulose

Properties:

Oral hypoglycemic agent, sulfonylurea derivative of the second generation. Stimulates insulin secretion by ß-cells of the pancreas. Increases the sensitivity of peripheral tissues to insulin. Apparently, it stimulates the activity of intracellular enzymes (in particular, muscle glycogen synthetase). Reduces the time from the moment you eat to the start of insulin secretion. Restores the early peak of insulin secretion, reduces the postprandial peak of hyperglycemia.

Gliclazide reduces platelet adhesion and aggregation, slows down the development of a parietal thrombus, and increases vascular

fibrinolytic activity. Normalizes vascular permeability. It has antiatherogenic properties: it lowers the concentration of total cholesterol (CS) and LDL-C in the blood, increases the concentration of HDL-C, and also reduces the amount of free radicals. Prevents the development of microthrombosis and atherosclerosis. Improves microcirculation. Reduces the sensitivity of blood vessels to adrenaline.

In diabetic nephropathy against the background of long-term use of gliclazide, there is a significant decrease in proteinuria.

Indications:

Diabetes mellitus type 2 with insufficient effectiveness of diet therapy, physical activity and weight loss.

Prevention of complications of type 2 diabetes mellitus: reducing the risk of microvascular (nephropathy, retinopathy) and macrovascular complications (myocardial infarction, stroke).

Method of administration and dosage:

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

The initial daily dose is 80 mg, the average daily dose is a maximum of 120 mg, the frequency of administration is 2 times / day before meals. It is recommended to take at the same time. Dosing is individual, depending on fasting blood glucose and 2 hours after meals, as well as on the clinical manifestations of the disease.

Contraindications:

Type 1 diabetes mellitus (insulin dependent), ketoacidosis, diabetic precoma and coma, severe renal and / or hepatic failure; pregnancy, breastfeeding period; children and adolescents up to 18 years old; hypersensitivity to sulfonylurea derivatives and sulfonamides. Simultaneous use of gliclazide and imidazole derivatives (including miconazole).

Precautions:

Gliclazide is used to treat non-insulin dependent diabetes mellitus in combination with a low-calorie, low-carbohydrate diet.

During treatment, you should regularly monitor fasting blood glucose and after meals, daily fluctuations in glucose levels.

With the development of hypoglycemia, if the patient is conscious, glucose (or sugar solution) is administered orally. In case of loss of consciousness, intravenous glucose or glucagon s / c, intramuscularly or intravenously is administered. After the restoration of consciousness, it is necessary to give the patient food rich in carbohydrates in order to avoid the re-development of hypoglycemia.

With the simultaneous use of gliclazide with verapamil, regular monitoring of blood glucose levels is necessary; with acarbose – careful monitoring and correction of the dosage regimen of hypoglycemic agents is required.

The simultaneous use of gliclazide and cimetidine is not recommended.

Side effects:

From the digestive system: rarely – anorexia, nausea, vomiting, diarrhea, epigastric pain.

From the hematopoietic system: in some cases – thrombocytopenia, agranulocytosis or leukopenia, anemia (usually reversible).

From the endocrine system: in case of overdose – hypoglycemia.

Allergic reactions: skin rash, itching.

Storage method:

In a cool dry place at a temperature not exceeding 30 degrees.

Packaging:

The cardboard box holds 10.20 or 30 tablets. paper instructions.