Glucovance 1000/5mg 30 tablets

Glucovance

Ingredients:

Each tablet contains:

Glibenclamide 5 mg

Metformin hydrochloride 1000 mg

Excipients:

Microcrystalline cellulose, sodium croscarmellose, povidone K 30, magnesium stearate.

Characteristics:

A combined oral hypoglycemic drug contains a second-generation sulfonylurea derivative and a biguanide. It has pancreatic and extrapancreatic action.

Glibenclamide is a second-generation sulfonylurea derivative. Stimulates insulin secretion by reducing the threshold of glucose irritation of pancreatic β-cells, increases insulin sensitivity and the degree of its binding to target cells, increases insulin release, enhances the effect of insulin on glucose absorption by muscles and liver, inhibits lipolysis in adipose tissue. Acts at stage II of insulin secretion.

Metformin belongs to the biguanide group. Stimulates peripheral tissue sensitivity to insulin (increases insulin binding to receptors, enhances the effects of insulin at the post-receptor level), reduces glucose absorption in the intestine, suppresses gluconeogenesis and has a beneficial effect on lipid metabolism, helps reduce excess body weight in patients with diabetes mellitus, and also has a fibrinolytic effect by suppressing tissue-type plasminogen activator inhibitor.

Indications:

Type 2 diabetes mellitus when diet therapy and previous therapy with sulfonylurea derivatives or biguanides, as well as other oral hypoglycemic agents, are ineffective.

Dosage and administration:

The drug is taken orally during meals.

The dosage regimen and duration of treatment are determined by the attending physician depending on the state of carbohydrate metabolism and blood glucose concentration.

The initial dose is usually 1 tablet/day, with further gradual selection of an effective dose until stable normalization of blood glucose concentration is achieved.

The maximum daily dose of the drug is 3 tablets.

Contraindications:

– type 1 diabetes mellitus;

– gestational diabetes mellitus;

– diabetic ketoacidosis, diabetic precoma, diabetic coma;

– lactic acidosis (including history);

— conditions accompanied by impaired absorption of food and the development of hypoglycemia;

– Impaired liver function;

- infectious diseases;

- hypoxic conditions (cardiac or respiratory failure, recent myocardial infarction, shock, severe respiratory disease);

– the period of 48 hours before and 48 hours after a radioisotope or X-ray examination with the introduction of an iodine-containing contrast agent;

– the period during 48 hours before and 48 hours after surgery;

– dystrophic diseases (myotonic dystrophy, lipodystrophy);

– leukopenia;

- porphyria;

chronic alcoholism, acute alcohol intoxication.

Precautions:

It is not recommended to use the drug in patients over 60 years of age who perform heavy physical work, which is associated with an increased risk of lactic acidosis.

The drug should be used with caution in case of fever syndrome; thyroid disease (with dysfunction); hypofunction of the anterior pituitary gland and / or adrenal cortex.

During treatment, patients should strictly follow the doctor's recommendations regarding the dosage and method of administration of the drug, as well as diet, exercise regimen and self-monitoring of blood glucose levels.

Side effects:

From the digestive system: rarely - nausea, vomiting, decreased appetite, abdominal pain, diarrhea, metallic taste in the mouth;

From the hematopoietic system: rarely - leukopenia, thrombocytopenia, erythropenia;

From the central nervous system: infrequently - headache.

From the skin: rarely - urticaria, erythema, itching, photosensitivity.

From the metabolism: rarely - hypoglycemia; very rarely - lactic acidosis.

Storage method:

Store at a temperature not exceeding 30 degrees.

Packaging:

A cardboard box contains 3 blisters of 10 tablets, paper instructions.