Trio-Clar 42 capsules

Tradename:

Trio-Clar

composition:

Each green capsule contains:

Omeprazole 20 mg

Each white tablet contains:

Clarithromycin 500 mg

Each yellow capsule contains:

Tinidazole 500 mg

Auxiliary components:

Mannitol, povidone, sodium croscarmellose, sodium lauryl sulfate, talc, magnesium stearate.

Properties:

Omeprazole inhibits gastric acid secretion due to specific inhibition of H + K + -AT Pase – an enzyme found in the membranes of parietal cells of the gastric mucosa. Reduces basal and stimulated secretion regardless of the nature of the stimulus. After a single oral administrati of the drug, the effect of omeprazole occurs within the first hour and lasts for 24 hours, t e maximum effect is achieved after 2 hours.

After stopping the drug intake, the secretory activity is fully restored after 3-5 days.

Clarithromycin is a semi-synthetic antibiotic from the group of broad-spectrum macrolides. It has an antimicrobial effect, which is associated with the suppression of protein synthesis by interacting with the 50S ribosomal subunit of a microbial cell. Effective against a large number of gram-positive, gram-negative aerobic and anaerobic microorganisms, including Helicobacter pylori. The metabolite 14-hydroxyclarithromycin formed in the body also has a pronounced antimicrobial activity.

Tinidazole inhibits synthesis and damages the DNA structure of bacteria. Has activity against anaerobic bacteria, protozoa and Helicobacter pylori.

Indications:

– eradication therapy of Helicobacter pylori in gastric ulcer and duodenal ulcer.

Method of administration and dosag

Take one omeprazole capsule, one clarithromycin tablet and one tinidazole capsule 2 times a day during or after meals in the morning and evening. Tablets and capsules must not be broken or chewed and must be swallowed whole.

Duration of treatment is 1-2 months.

Contraindications:

-increased sensitivity to omeprazole, clarithromycin or tinidazole, as well as to antibiotics of the macrolide group;

• combined use with cisapride, pimozide, astemizole, terfenadine, ethanol is prohibited;

-pregnancy;

• lactation period;

-organic diseases of the central nervous system;

-porphyria;

• suppression of bone marrow hematopoiesis; -childhood;
• renal and / or hepatic impairment.

Precautions:

Before starting therapy, it is necessary to exclude the presence of a malignant process, because treatment, masking the symptoms, can delay the correct diagnosis.

It is prescribed with caution while taking medications metabolized by the liver. In the case of a joint appointment with warfarin or other indirect anticoagulants, it is necessary to control the prothrombin time.

With a history of heart disease, concomitant use with terfenadine, cisapride, astemizole is not recommended.

Tinidazole causes dark discoloration of urine.

Influence on the ability to drive vehicles and control mechanisms:

During the period of treatment, care must be

taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Side effects:

On the part of the digestive system: dysbiosis, diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disturbance, metallic taste in the mouth, decreased appetite, stomatitis, transient increase in the activity of liver enzymes in plasma, impaired liver function, hepatitis (including jaundice), in patients with previous liver disease – encephalopathy; rarely pseudomembranous enterocolitis.

From the side of the central nervous system: headache, dizziness, agitation, fatigue, weakness, drowsiness, insomnia, ataxia, paresthesia, depression, confusion, hallucinations, epileptic reactions, peripheral neuropathy, convulsions, fear, nightmares, disorientation, psychosis, depersonalization, noise in ears.

From the musculoskeletal system: muscle weakness, myalgia, arthralgia.

From the hematopoietic system: leukopenia, neutropenia, thrombocytopenia, thrombocytopenic purpura, anemia.

On the part of the skin: itching; rarely – skin rash; in some cases – photosensitivity, exudative erythema multiforme, alopecia.

Allergic reactions: urticaria, angioedema, bronchospasm and anaphylactic shock.

Others: tachycardia, interstitial nephritis, visual impairment, peripheral edema, increased sweating, fever, gynecomastia.

Storage method:

At a temperature not higher than 25 degrees.

Packaging:

The cardboard box contains 7 blisters of 2 Tinidazole capsules, 2 Omeprazole capsules and 2 Clarithromycin tablets, paper instructions.