Terbin 1% cream 15 g

Tradename:

Terbin

Terbin

Composition:

Each gram of cream contains 1.0% terbinafine hydrochloride

Properties:

Antifungal drug for topical use with a broad spectrum of antifungal activity. Even in small concentrations, terbinafine has a fungicidal effect against dermatophytes (Trychophyton rubrum, T.mentagrophytes, T.verrucosum, T.violaceum, T.tonsurans, Microsporum canis, Epidermophyton floccosum), molds (mainly C. albicans) and certain dimorphic fungi (Pityrosporum orbiculare). Activity against yeast fungi, depending on their type, can be fungicidal or fungistatic.

Terbinafine specifically alters the early stage of sterol biosynthesis in fungi. This leads to a deficiency of ergosterol and intracellular accumulation of squalene, which causes the death of the fungal cell. Terbinafine works by

inhibiting the enzyme squalene epoxidase located on the cell membrane of the fungus.

Terbinafine has no effect on the cytochrome P450 system in humans and, accordingly, on the metabolism of hormones or other drugs.

Indications:

• prevention and treatment of fungus, fungal infections of the skin, including mycoses of the feet (“fungus” of the foot), inguinal epidermophytosis (tinea cruris), fungal lesions of the smooth skin of the body (tinea corporis) caused by dermatophytes such as Trichophyton (including T. rubrum, T.

mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum;

• yeast infections of the skin, mainly those caused by the genus Candida (for example, Candida albicans), in particular diaper rash;

versicolor versicolor (Pityriasis versicolor), caused by Pityrosporum orbiculare (also known as Malassezia furfur).

Method of administration and dosage:

Adults and children from 12 years old:

Before applying the cream, it is necessary to clean and dry the affected areas. The cream is applied once or twice a day with a thin layer on the affected skin and adjacent areas and rubbed lightly. For infections accompanied by diaper rash (under the mammary glands, in the interdigital spaces, between the buttocks, in the groin area), the places where the cream is applied can be covered with gauze, especially at night.

Average duration of treatment:

dermatomycosis of the trunk, legs – 1 week, once a day; dermatomycosis of the feet – 1 week, 1 time per day; candidiasis of the skin 1-2 weeks 1 or 2 times a day; tinea versicolor: 2 weeks 1 or 2 times a day.

Contraindications:

– hypersensitivity to terbinafine or to any of the inactive ingredients that make up the drug.

With care: hepatic and / or renal failure, alcoholism, inhibition of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular disease of the extremities, children under 12 years of age (lack of sufficient clinical experience).

Precautions:

A decrease in the severity of clinical manifestations is usually noted in the first days of treatment. In the case of irregular treatment or premature termination of it, there is a risk of recurrence of the infection.

Terbin Cream is for external use only. Avoid contact with eyes as it may cause irritation. In case of accidental contact of the drug in the eyes, they should be immediately rinsed with running water, and in case of persistent irritation, consult a doctor.

With the development of allergic reactions, it is necessary to cancel the drug.

Side effects:

In places where the drug is applied, redness, itching or burning sensation may appear. Allergic reactions.

Storage method:

At a temperature not higher than 25 degrees. In a dry place.

Packaging:

Tubes of 15 g.