Sugarlo 50 mg

Trade Name:

Sugarlo

Composition:

Each tablet contains:

Vildagliptin 50 mg

Inactive ingredients:

Lactose anhydrous, microcrystalline cellulose, magnesium stearate

Properties:

Hypoglycemic agent.

Vildagliptin is a representative of the class of pancreatic islet stimulants that selectively inhibits the enzyme dipeptidyl peptidase-4 (DPP-4). Rapid and complete inhibition of DPP-4 activity (>90%) causes an increase in both basal and food-stimulated secretion of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) from the intestine into the systemic circulation throughout the day.

Indications:

Type 2 diabetes mellitus: as monotherapy in combination with diet and exercise; as part of a two-component combination therapy with metformin, sulfonylurea derivatives, thiazolidinedione or insulin in case of failure of diet therapy, exercise and monotherapy with these drugs.

Dosage and administration:

The optimal dosing regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

The dosage regimen is set individually depending on the effectiveness, tolerability and treatment regimen.

Single dose – 50 mg, daily dose – 100 mg (50 mg 2 times / day).

Contraindications:

Hypersensitivity to vildagliptin.

Warnings and precautions:

Not recommended for use in patients with severe hepatic impairment, incl. with an increase in ALT or AST activity > 2.5 times higher than ULN.If jaundice or other signs of liver dysfunction develop, vildagliptin therapy should be discontinued immediately.

If insulin therapy is required, vildagliptin is used only in combination with insulin.

Vildagliptin should not be used to treat type 1 diabetes mellitus or to treat diabetic ketoacidosis.

Side effects :

From the digestive system: sometimes – constipation; rarely – liver dysfunction (including hepatitis) of an asymptomatic course; when combined with insulin often – nausea, flatulence, GERD.

From the side of the central nervous system: often – tremor, dizziness, headache.

From the side of metabolism: often – hypoglycemia, weight gain. Allergic reactions: rarely – angioedema (more often in combination with ACE inhibitors).

Other: often – asthenia, peripheral edema. 

Storage:

Store at a temperature not exceeding 30°C.

Package:

The carton box contains 3 blisters of 10 tablets and paper leaflet.