Xilopred 16 mg 20 tablets

Xilopred 16 mg 20 tablets

Composition: 

Each tablet contains methylprednisolone 16 mg.

Product Description: 

Xilopred is a synthetic glucocorticosteroid with anti‑inflammatory, immunosuppressive, and anti‑allergic properties.
It is prescribed for conditions requiring systemic hormonal therapy.

Indications for Use: 

• Endocrine disorders such as adrenal insufficiency and congenital adrenal hyperplasia.
  
• Rheumatic diseases including rheumatoid arthritis and juvenile arthritis.
  
• Autoimmune conditions such as systemic lupus erythematosus and dermatomyositis. 
  
• Severe allergic disorders including rhinitis, bronchial asthma, and serum sickness. 
  
• Dermatological diseases such as pemphigus vulgaris. 
  
• Hematological disorders including idiopathic thrombocytopenic purpura. 
  
• Malignant diseases such as leukemias and lymphomas. 
  
• Gastrointestinal conditions including ulcerative colitis and Crohn’s disease. 
  
• Other indications include sarcoidosis and tuberculous meningitis (in combination with anti‑tuberculosis therapy).

Method of Administration and Dosage: 

The initial dose depends on the specific disease and is determined by the physician.
Maintenance therapy should be the minimal effective dose, taken once daily in the morning or every other day.
Withdrawal must be gradual under medical supervision.
In children and elderly patients, use with caution and at the lowest effective dose.

Contraindications: 

Systemic fungal infections, hypersensitivity to methylprednisolone or excipients, live vaccination during immunosuppressive therapy, and severe infections without specific treatment.

Precautions: 

• Increased susceptibility to bacterial, viral, and fungal infections.
  
• Endocrine effects include adrenal suppression and Cushing’s syndrome. 
  
• Gastrointestinal risks include ulcers, perforation, and pancreatitis. 
  
• Cardiovascular risks include hypertension and thrombosis. 
  
• Nervous system effects may include psychiatric reactions such as depression or mania. 
  
• Ophthalmic risks include cataracts and glaucoma. 
  
• Metabolic disturbances include hyperglycemia and hypokalemia. 
  
• Skeletal effects include osteoporosis, especially in postmenopausal women.

Adverse Reactions (Side Effects): 

Common reactions include sleep disturbances, weight gain, edema, dyspepsia, and hyperglycemia.
Rare reactions include thrombosis, osteoporosis, psychiatric disturbances, cataracts, and glaucoma.
Long‑term use may result in adrenal insufficiency.

Pregnancy and Lactation: 

During pregnancy, use only if strictly indicated due to risk of fetal growth retardation.
During lactation, methylprednisolone is excreted in breast milk; use with caution.

Storage Conditions: 

Store below 30°C in a dry place, protected from light.

Packaging: 

Carton box containing two blisters of 10 tablets each.