Itracon 100 mg 14 capsules

Tradename:

Itracon

Itracon

Composition:

Each capsule contains:

Itraconazole 100 mg

Auxiliary components:

Hydroxypropyl cellulose, poloxamer, polyethylene glycol.

Properties:

Triazole derivative antifungal agent. The mechanism of action is associated with the ability to inhibit cytochrome P450-dependent enzymes of sensitive fungi, which leads to disruption of the synthesis of ergosterol in the cell wall of the fungus. Has a broader spectrum of antifungal activity than ketoconazole. Active against Aspergillus spp., Blastomyces dermatitidis, Candida, Coccidioides immitis, Cryptococcus neoformans, Epidermophyton, Microsporum, Trichophyton, Histoplasma capsulatum, Malassezia furfur, Paracoccidioides brasiliensis, Spheniickii.

Indications:

Vulvovaginal candidiasis, mycoses of the skin, oral cavity, eyes, onychomycosis caused by dermatophytes and / or yeasts, systemic mycoses (including systemic aspergillosis, candidiasis, cryptococcosis, histoplasmosis, sporotrichosis, paracoccidioidosis, blastomycosis and other rare systemic and tropical mycoses).

Method of administration and dosage:

The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

Inside, 100 mg 1 time / day or 200 mg 1-2 times / day, the duration of treatment depends on the etiology of the disease.

Contraindications:

Simultaneous ingestion of terfenadine, astemizole, mizolastine, cisapride, dofetilide, quinidine, pimozide, simvastatin, lovastatin, midazolam or triazolam; hypersensitivity to itraconazole.

Precautionary measures:

Should not be used in patients with symptoms of ventricular dysfunction and a history of congestive heart failure.

Itraconazole should not be used in patients with liver disease. However, in cases of extreme necessity with liver cirrhosis and / or impaired renal function, treatment with itraconazole is carried out under the control of its plasma level and with an appropriate dose adjustment.

With an increase in the activity of liver transaminases, itraconazole is used in cases where the expected benefit of therapy outweighs the possible risk of liver damage.

In the case of using itraconazole for more than 1 month, monitoring of liver function is necessary.

If symptoms of heart failure, liver dysfunction, peripheral neuropathy develop during treatment, itraconazole should be discontinued.

Itraconazole is used with caution in case of hypersensitivity to other azole derivatives.

Use in pediatrics

There is currently insufficient data on the use of itraconazole in children.

Side effects:

From the side of the digestive system: abdominal pain, nausea, vomiting, constipation, increased activity of liver enzymes, cholestatic jaundice; in some cases – hepatitis.

From the side of the central nervous system and peripheral nervous system: headache, dizziness; in some cases, peripheral neuropathy.

From the side of the cardiovascular system: in some cases – edema, congestive heart failure and pulmonary edema.

Allergic reactions: skin rash, pruritus, urticaria, angioedema, Stevens-Johnson syndrome.

Others: with prolonged use – dysmenorrhea, hair loss, hypokalemia.

Storage method:

At a temperature not higher than 30 degrees. In a dry place

Package:

The cardboard box holds 4 or 14 capsules, paper instructions.