Flagyl 500 mg 20 tablets

Trade name:

flagyl

Flagil

Compound:

Each tablet contains:

Metronidazole 500 mg

Auxiliary components:

microcrystalline cellulose, calcium stearate, potato starch.

Properties:

Synthetic antibacterial and antiprotozoal drug of the 5-nitroimidazole group. The drug has an antibacterial, antiprotozoal effect. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of microorganism cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

Indications:

Infections caused by anaerobic pathogens: wound infection, infection of the respiratory system, urinary tract, intestines; prevention of anaerobic infection before intestinal surgery; trichomoniasis, amoebiasis, giardiasis, Crohn’s disease.

Dosage and administration:

Inside, during or after a meal, without chewing.

The course of treatment is determined by the doctor after the tests: On average, the course of treatment: Children 2-5 years old – 250 mg / day; 5-10 years – 250-375 mg / day, children 10-15 years old – 500 mg / day and adults – 500 mg 2-3 times a day. The course of treatment is 5-10 days.

With severe renal impairment (CC less than 10 ml / min), the daily dose should be halved.

Contraindications:

– leukopenia (including history);

-organic lesions of the central nervous system (including epilepsy);

– liver failure (in case of high doses);

-pregnancy (I trimester);

– lactation period;

-increased sensitivity.

With caution – pregnancy (II, III trimesters), renal / liver failure.

Precautionary measures:

During the treatment period, ethanol is contraindicated (possible development of a disulfiram-like reaction: spastic abdominal pain, nausea, vomiting, headache, sudden rush of blood to the face).

In combination with amoxicillin, it is not recommended for use in patients under 18 years of age.

With prolonged therapy, it is necessary to control the blood picture.

With leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process.

The appearance of ataxia, dizziness and any other deterioration in the neurological status of patients requires discontinuation of treatment.

May immobilize treponema and lead to a false positive Nelson test.

Colors urine dark.

In the treatment of trichomonas vaginitis in women and trichomonas urethritis in men, it is necessary to refrain from sexual activity. Mandatory simultaneous treatment of sexual partners. Treatment does not stop during menstruation. After therapy for trichomoniasis, control tests should be carried out for three regular cycles before and after menstruation.

After treatment of giardiasis, if symptoms persist, perform 3 fecal analyzes after 3-4 weeks at intervals of several days (in some successfully treated patients, lactose intolerance caused by invasion may persist for several weeks or months, resembling the symptoms of giardiasis).

Side effects:

From the digestive system: diarrhea, anorexia, nausea, vomiting, intestinal colic, constipation, metallic taste in the mouth, dry mouth, glossitis, stomatitis, pancreatitis.

From the nervous system: dizziness, incoordination, ataxia, confusion, irritability, depression, irritability, weakness, insomnia, headache, convulsions, hallucinations, peripheral neuropathy.

Allergic reactions: urticaria, skin rash, skin flushing, nasal congestion, fever, arthralgia.

From the genitourinary system: dysuria, cystitis, polyuria, urinary incontinence, candidiasis, staining of urine in red-brown color.

Others: neutropenia, leukopenia, flattening of the T wave on the ECG.

Storage method:

In a dry cool place at a temperature not exceeding 25 degrees.

Package:

Cardboard box contains 2 blisters of 10 tablets