Betnovate-C cream 15 g

Tradename:

Betnovate-C

Betnovate – C

Composition:

Each gram of cream contains:

Batamethasone 17-valerate 0.1%

Clioquinol 3%

Auxiliary components: Chlorocresol, cetomacrogol, soft paraffin, liquid paraffin, phosphoric acid, sodium hydroxide, purified water.

Properties:

A combination, the action of which is due to the components that make up it.

Betamethasone is a synthetic corticosteroi which has anti-inflammatory, anti-allergic, antipruritic and vasoconstrictor effects. When applied topically, it narrows blood vessels,

eliminates itching, reduces the release of inflammatory mediators (from eosinophils and mast cells), IL-I and IL-2, y-interferon (from lymphocytes and macrophages), inhibits the activity of hyaluronidase and reduces the permeability of the vascular wall. Interacts with specific receptors in the cytoplasm of the cell, stimulates the synthesis of mRNA, which induces the formation of proteins, incl.

lipocortin mediating cellular effects. Lipocortin inhibits phospholipase A2, blocks the release of arachidonic acid and the biosynthesis of endoperoxides, PG, LT (contributing to the development of inflammation, allergies and other pathological processes).

Clioquinol is an antimicrobial agent for external use, a derivative of 8-hydroxyquinoline.

Clioquinol is active against dermatophytes and yeasts (Microsporum spp., Trichophyton spp., Candida albicans) and gram-positive bacteria (Staphylococcus spp., Enterococcus spp.).

Indications:

dermatoses, allergic and inflammatory skin diseases amenable to GCS therapy, in the presence of a secondary infection caused b microorganisms susceptible to gentamicin, or if such an infection is suspected, incl. eczema (atopic, children’s, coin-like), dermatitis (contact, allergic, seborrheic, atopic, solar, exfoliative, radiation), neurodermatitis, diaper rash, psoriasis, lichen planus, phleboderma, pyoderma, anogenital and senile pruritus. It is used for skin lesions against the background of eczema or psoriasis, for diseases of wet or oily skin. Skin infections caused by microorganisms sensitive to clioquinol.

Method of administration and dosage:

Apply externally to damaged skin, once or twice a day for 4 weeks. Children: Consult a physician before use.

Contraindications:

Hypersensitivity, bacterial (skin tuberculosis, skin manifestations of syphilis), fungal, viral (chickenpox, herpes simplex) skin diseases, post-vaccination skin reactions, open wounds, trophic ulcers of the leg, rosacea, acne vulgaris, skin cancer, nevus, atheroma, melanoma , hemangioma, xanthoma, sarcoma, children under 1 year of age (cream and ointment), breastfeeding period.

With care: Cataract, diabetes mellitus, glaucoma, tuberculosis (with prolonged use or

application to large areas of the body), children from 2 to 12 years old.

Precautions:

With prolonged use, the development of microflora resistance to clioquinol is possible. Long-term use of the drug on the skin of the face is not recommended, since rosacea, perioral dermatitis and acne may develop. The course of treatment should not exceed 5 days. The medicinal product is not intended for use in ophthalmology. Avoid contact with eyes. If the drug gets on the mucous membranes of the eye, it is possible to develop cataracts, glaucoma, fungal infections of the eye and exacerbation of herpes infection. With prolonged treatment, when applied to extensive skin surfaces, as well as in the armpits and groin folds, when using occlusive dressings, diapers, systemic absorption of GCS is possible.

Side effects:

Skin and subcutaneous tissue disorders:

itching, burning, irritation, dry skin, folliculitis, hypertrichosis, striae, acne-like rashes (“steroid” acne), hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin

maceration, secondary infection, skin atrophy, local hirsutism, telangiectasia, prickly heat, purpura.

On the part of laboratory parameters: hyperglycemia, glucosuria.

From the side of the organ of vision: blurred vision.

Others: reversible suppression of the adrenal cortex function, manifestation of ItsenkoCushing’s syndrome.

Storage method:

At a temperature not higher than 30 degrees.

Packaging:

The cardboard box holds a 15 gram tube.