Elidel 1% cream 15 g

Tradename:

Elidel

Elidel

Structure:

Each gram of cream contains:

10 mg pimecrolimus

Auxiliary components:

sodium hydroxide, citric acid anhydrous, benzyl alcohol, sodium cetostearyl sulfate, mono- and diglycerides, cetyl alcohol, stearyl alcohol, propylene glycol, Oleyl alcohol, medium-chain triglycerides, purified water

Properties:

Pimecrolimus – a derivative of the macrolactam ascomycin, has an anti-inflammatory effect. Selectively inhibits the production and release of cytokines and mediators from Tlymphocytes and mast cells.

Pimecrolimus specifically binds to the cytosolic receptor macrophilin-12 and inhibits calciumdependent phosphatase – calcineurin.

Calcineurin inhibition leads to suppression of the proliferation of T-lymphocytes and prevents the transcription and production of early cytokines in T-helpers 1 and 2, such as interleukin-2, interferon gamma, interleukin interleukin-5, interleukin-10, tumor necrosi factor a and granulocyte-macrophage colonystimulating factor. Pimecrolimus and

tacrollmus equally suppress the secondary immune response in isolated cell colonies of skin T-helpers obtained from patients with atopic dermatitis.

Indications:

Atopic dermatitis (eczema).

The drug is indicated for short-term and longterm use in adults, adolescents and children (over 2 years old).

Method of administration and dosage:

The cream is applied in a thin layer on the affected surface 2 times / day and rubbed gently until completely absorbed.

The cream can be applied to the skin of any part of the body, including the head, face, neck, and diaper rash.

The cream should be applied 2 times / day until the symptoms disappear completely.

Contraindications:

• children under 2 years of age (since the

safety and efficacy of using Elidel cream in children under 2 years of age has not been studied);

-Application of Elidel cream to skin areas affected by an acute viral, bacterial or fungal infection;

• hypersensitivity to pimecrolimus or any components of the drug.

Precautions:

When treating with Elidel cream, patients are advised to minimize artificial or natural skin insolation or completely avoid ultraviolet radiation. The possible effect of the use of the drug on skin lesions caused by ultraviolet radiation is unknown.

Side effects:

Often: local reactions (irritation, itching and redness of the skin), skin infections (folliculitis).

Sometimes: suppuration, worsening of the disease, herpes simplex, dermatitis caused the herpes simplex virus (herpetic eczema), molluscum contagiosum; local reactions such

as rash, pain, paresthesias, peeling, dryness, swelling, cutaneous papillomas, boils.

Storage method:

At a temperature not higher than 30 degrees.

Packaging:

The cream is available in tubes of 5g, 15g, 30g, 60g and 100g.