Amri K 10 mg/1 ml 5 ampoules

Amri K 10 mg/1 ml 5 ampoules

Composition:

Phytomenadione (Vitamin K1) — 10 mg (per 1 ml ampoule).
Excipients:
Polysorbate 80, Propylene glycol, Sodium acetate, Glacial acetic acid, Water for injections.

Product Description:

Amri‑K is a Vitamin K1 preparation essential for hepatic synthesis of clotting factors of the prothrombin complex.
It acts as a microsomal enzyme cofactor, catalyzing post‑translational carboxylation of glutamic acid residues in precursor molecules of clotting factors.
Vitamin K1 also participates in the formation of gamma‑carboxyglutamic acid residues in bone tissue and kidneys.

Indications for use:

Hemorrhagic syndrome with hypoprothrombinemia (low prothrombin or factor VII levels).
Prophylaxis in patients predisposed to hemorrhage associated with reduced prothrombin or factor VII levels.

Method of administration and dosage:

• Administer parenterally (for less severe bleeding) or intravenously (as an antidote for anticoagulant overdose).
• Adults: 10–40 mg in cases of severe bleeding.
• Children over 2 years: 1–5 mg depending on condition.
• Elderly patients may require lower doses. 
• The drug may be used together with blood transfusion or administration of clotting factor concentrates.

Contraindications:

Hypersensitivity to any component of the drug.

Precautions:

Vitamin K1 affects clotting processes; sufficient time is required for synthesis of clotting factors.
Effect usually appears within 6–10 hours, with full effect in 1–2 days.
Vitamin K1 acts as an antagonist to coumarin‑based anticoagulants.

Side effects:

Rare reports of anaphylactoid reactions after parenteral administration.
Rare injection site reactions, which may be severe: inflammation, tissue necrosis, redness, sweating, taste disturbances.

Pregnancy and lactation:

Use only under medical supervision, considering benefit versus potential risk.

Storage conditions:

Store at temperatures not exceeding 30 °C.

Packaging:

Carton box contains 5 ampoules of 1 ml and an instruction leaflet.