Amri-K 10mg / ml 1 ml 5 amp

Amri – K (Amri – K)

Each 1 ml ampoule contains:

Phytomenadione (Vitamin K1) 10 mg

Auxiliary components:

polysorbate 80, propylene glycol, sodium acetate, glacial acetic acid, water for injection.

Vitamin K1 is necessary for the production of coagulation factors of the prothrombin complex in the liver. It is a microsomal coenzyme enzyme that catalyzes the post-translational carboxylation of glutamic acid residues in the precursor molecule of the aforementioned coagulation factors.

Vitamin K1 is involved in the formation of gamma-carboxyglutamic acid residues in bone tissue and kidneys.

Indications:

– with hemorrhagic syndrome (increased bleeding) with hypoprothrombinemia (decreased blood levels of prothrombin or blood clotting factor VII);

– for the prevention of patients with a predisposition to hemorrhage associated with low blood levels of prothrombin or blood clotting factor VII.

The drug is administered parenterally (with less severe bleeding) and intravenously (as an antidote for overdose of antithrombotic drugs, anticoagulants).

The dose used in treatment depends on the form of the disease (including the type of hypoprothrombinemia and its severity, age).

The drug may be more effective in the elderly, and lower doses of vitamin K1 are generally recommended for this group of patients.

Usual Adult Doses: 10 mg to 40 mg (in case of heavy bleeding).

Usual dosages for children over 2 years of age: 1 mg to 5 mg. This range is indicative and depends on the patient’s condition.

The drug is sometimes used in conjunction with a blood transfusion or clotting factor concentrate.

Amri-K is not used in patients with a hypersensitivity reaction to its composition.

Vitamin K1 affects the clotting processes, you should wait for the right time to synthesize most of the clotting factors. The effect does not appear immediately. Usually it can be expected in 6-10 hours. Full effect in 1-2 days.

Vitamin K1 has an antagonistic (opposite) effect in relation to antithrombotic drugs based on coumarin.

There have been rare reports of anaphylactoid reactions after parenteral administration of Amri-K.

In rare cases, injection site reactions can occur that can be serious, including inflammation, tissue necrosis, redness, sweating, and taste disturbances.

Store at a temperature not exceeding 30 degrees.

The cardboard box contains 5 ampoules of 1 ml, paper instructions.