Avodart 0.5 mg capsules

Trade name:

Avodart

Avodart

Composition:

Each capsule contains:

Dutasteride 0.5 mg

Auxiliary components:

glycerin monocaprilocaprate type l, butylhydroxytoluene, gelatin, glycerol

(glycerin), methyl parahydroxybenzoate, propyl parahydroxybenzoate, titanium dioxide, iron dye yellow oxide.

Properties:

An agent for the treatment of benign prostatic hyperplasia. Suppresses the activity of type 1 and type 2 5a-reductase isoenzymes, which are responsible for the conversion of testosterone to 5a-dihydrotestosterone. Dihydrotestosterone is the main androgen responsible for hyperplasia of the glandular tissue of the prostate.

The maximum effect of dutasteride on the decrease in dihydrotestosterone concentrations is dose-dependent and is observed after 1-2 weeks. after starting treatment. After 1 and 2 weeks. taking dutasteride at a dose of 0.5 mg / day, the mean serum dihydrotestosterone concentrations are reduced by 85% and 90%.

Dutasteride helps to shrink the prostate gland, improve urination and reduce the risk of acute urinary retention and the need for surgery.

Indications:

Treatment and prevention of progression of benign prostatic hyperplasia.

Method of administration and dosage:

The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

For adult men, including elderly patients, the recommended oral dose is 0.5 mg 1 time / day. Treatment should be continued for at least 6 months.

Contraindications:

Hypersensitivity to dutasteride and other 5 reductase inhibitors; use in women and children is contraindicated.

Precautionary measures:

It should be used with caution in patients with impaired liver function. dutasteride undergoes intense metabolism in the liver, and its Tl / 2 is 3-5 weeks.

In patients with benign prostatic hyperplasia, digital rectal examination and other methods of examining the prostate gland should be performed before starting treatment with dutasteride and periodically repeated during treatment to exclude the development of prostate cancer.

Determination of serum PSA concentrations is an important component of a set of studies aimed at detecting prostate cancer. A baseline PSA level of less than 4 ng / ml in patients receiving dutasteride does not preclude a diagnosis of prostate cancer.

Dutasteride is absorbed through the skin, therefore women and children should avoid contact with the active substance. In case of such contact, immediately wash the affecte area of skin with soap and water.

Side effects:

From the reproductive system: erectile dysfunction, change (decrease) in libido, impaired ejaculation, gynecomastia (includes tenderness and enlargement of the mammary glands).

Allergic reactions: rash, itching, urticaria, localized edema, angioedema.

On the part of the skin and subcutaneous fat: alopecia (mainly loss of body hair) or hypertrichosis.

Storage method:

At a temperature not higher than 30 C.

Packaging:

The cardboard box contains 3 blisters of 10 capsules.