Zyloric 300 mg 30 tablets

Zyloric

Zilorik

Each tablet contains:

100 mg allopurinol

Auxiliary components:

lactose monohydrate (milk sugar) – 49.00 mg; MCC – 20.00 mg; sodium carboxymethyl starch (primogel) – 20.00 mg; food gelatin – 5.00 mg; magnesium stearate – 4.00 mg; colloidal silicon dioxide (aerosil) – 2.00 mg

Allopurinol is an anti-gout drug that inhibits the synthesis of uric acid and its salts in the body. The drug has the specific ability to inhibit the xanthine oxidase enzyme involved in the conversion of hypoxanthine to xanthine and xanthine to uric acid. As a result, the content of urates in the blood serum decreases, which prevents their deposition in tissues and kidneys.

Allopurinol in the body is converted to oxypurinol (alloxanthin), which also prevents the formation of uric acid, but is inferior in activity to allopurinol.

Treatment and prevention of gout and hyperuricemia of various origins (including in combination with nephrolithiasis, renal failure, urate nephropathy). Recurrent mixed calcium oxalate kidney stones in the presence of hyperuricosuria. Increased formation of urates due to enzyme disorders. Prevention of acute nephropathy with cytostatic and radiation therapy of tumors and leukemias, as well as with complete medical fasting.

Inside, after meals, with plenty of water, 1 time per day.

Doses are set individually, under the control of the concentration of urates and uric acid in the blood and urine. Adults when taken orally – 100-900 mg / day, depending on the severity of the disease. The frequency of admission is 2-4 times / day after meals. Children under 15 years old – 10-20 mg / kg / day or 100-400 mg / day.

Maximum doses: for impaired renal function (including those caused by urate nephropathy) – 100 mg / day. An increase in the dose is possible in cases where, against the background of the therapy, an increased concentration of urates in the blood and urine remains.

– hypersensitivity to allopurinol or to other components of the drug;

– severe violations of liver or kidney function;

-During pregnancy and breastfeeding;

-Children under 3 years old.

The use of the drug by patients with renal insufficiency, as well as with disorders of hematopoiesis, should be carried out under the constant supervision of a physician.

Skin reactions are the most common and can occur at any time during treatment, if they occur, allopurinol should be discontinued immediately.

From the side of metabolic processes:

– at the beginning of the course of treatment, an acute attack of gout may occur due to the mobilization of uric acid from gouty nodules and other depots.

From the gastrointestinal tract and liver:

– nausea, vomiting, diarrhea, reversible increase in the level of transaminases and alkaline phosphatase in the blood, hepatitis, stomatitis, acute cholangitis.

From the side of the central nervous system:

– dizziness, headache, drowsiness, weakness, fatigue, ataxia, depression, convulsions, paresis, paremesia, neuropathy, peripheral neuritis, myalgia.

Allergic reactions.

In a cool dry place at a temperature not exceeding 25 degrees.

The cardboard box holds 3 blisters of 10 tablets.