Feburic 80 mg 30 tablets

Feburic 80 mg 30 tablets

Composition:

Each film‑coated tablet contains febuxostat 80 mg.
Excipients include lactose monohydrate, hypromellose, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, and purified water.

Description:

Feburic is a xanthine oxidase inhibitor that reduces uric acid production by blocking the oxidation of hypoxanthine to xanthine and xanthine to uric acid.
Compared with allopurinol, febuxostat provides a more effective and sustained reduction in serum uric acid levels.
It is indicated for chronic hyperuricemia associated with gout and, at higher doses, for prevention of tumor lysis syndrome in patients undergoing cytotoxic therapy.

Indications for Use:

Chronic hyperuricemia in adults with gout, including those with tophi or gouty arthritis.
Prevention and treatment of hyperuricemia in adult patients receiving cytostatic therapy for hematological malignancies with moderate to high risk of tumor lysis syndrome (only at 120 mg dosage).

Method of Administration and Dosage:

Feburic is taken orally once daily.
The recommended dose is 80 mg once daily, with the option to increase to 120 mg if serum uric acid remains above target.
The therapeutic goal is to maintain serum uric acid below 6 mg/dL (357 µmol/L).
Treatment duration is individualized.
Therapy should begin only after resolution of an acute gout attack.

Contraindications:

Hypersensitivity to febuxostat or excipients.
Pregnancy and breastfeeding.
Pediatric use under 18 years of age.

Precautions:

Febuxostat may precipitate acute gout attacks at initiation due to mobilization of urate deposits.
Prophylaxis with NSAIDs or colchicine for at least 6 months is recommended.
Liver function should be monitored at baseline and periodically.
Caution is advised in patients with cardiovascular disease.
Febuxostat may cause drowsiness, dizziness, paresthesia, or blurred vision, which can impair driving and operating machinery.

Adverse Reactions (Side Effects):

• Nervous system: headache (common), dizziness, paresthesia, drowsiness, altered taste, hypesthesia, hyposmia.
• Respiratory system: cough, bronchitis.
• Hematopoietic system: leukopenia, anemia, thrombocytopenia.
• Cardiovascular system: angina pectoris, arrhythmias, hypertension.
• Digestive system: nausea, diarrhea.
• Musculoskeletal system: arthralgia, myalgia.
• Dermatological reactions: dermatitis, urticaria, alopecia.
• Urinary system: hematuria, polyuria, renal impairment, nephrolithiasis.
• Reproductive system: erectile dysfunction, gynecomastia, mastalgia.
• Allergic reactions: rash, hypersensitivity.

Pregnancy and Lactation:

Contraindicated during pregnancy and breastfeeding due to lack of safety data and potential risk to the fetus or infant.

Storage Conditions:

Store in a dry, cool place at temperatures not exceeding 30°C.
Protect from moisture.

Packaging:

Carton box containing 30 film‑coated tablets