Anticox II 15 mg/3 ml 6 ampoules

ANTICOX II 15 mg / 3 ml solution for injection

Composition

Active ingredient:

Meloxicam – 15 mg per 3 ml ampoule

Description

ANTICOX II is a non-steroidal anti-inflammatory drug (NSAID) presented as a solution for intramuscular injection. It contains meloxicam, which provides analgesic, antipyretic, and anti-inflammatory effects. The injectable form is used when oral administration is not feasible and is indicated for the short-term treatment of acute rheumatoid arthritis and ankylosing spondylitis.

Indications for Use

Short-term symptomatic treatment of acute rheumatoid arthritis

Treatment of ankylosing spondylitis

Only for adult use when oral administration is not possible

Dosage and Method of Administration

Standard dose: 1 ampoule (15 mg) once daily

Do not exceed 15 mg/day

Treatment is generally limited to a single injection, with a maximum of 2–3 days in exceptional cases

Administer by deep intramuscular injection into the upper outer quadrant of the buttock

Always aspirate before injection to avoid intravascular administration

Switch to oral treatment as soon as possible

Special populations:

Elderly or high-risk patients: Start with 7.5 mg (half ampoule)

End-stage renal failure on dialysis: Do not exceed 7.5 mg/day

Contraindicated in children under 18, patients with severe hepatic or renal impairment

Contraindications

Hypersensitivity to meloxicam or excipients

History of NSAID-induced asthma, urticaria, angioedema

Active or recurrent peptic ulcer or GI bleeding

Severe hepatic or renal insufficiency

GI or cerebrovascular bleeding

Heart failure

Children and adolescents under 18

Pregnancy (third trimester) and breastfeeding

Perioperative pain management in CABG surgery

Bleeding disorders or concurrent anticoagulant therapy (IM contraindication)

Precautions

Use lowest effective dose for shortest possible duration

Avoid combination with other NSAIDs

Increased risk of GI bleeding, ulceration, perforation (especially in elderly)

Monitor renal and liver function in at-risk patients

NSAIDs may cause fluid retention, hypertension, worsening of heart failure

Risk of serious skin reactions (Stevens-Johnson, Lyell’s syndrome)

Use with caution in patients with GI, cardiovascular, renal, or hepatic risk factors

May reduce female fertility during use

Side Effects

Very common: GI symptoms – nausea, vomiting, dyspepsia, abdominal pain, diarrhea

Common: Headache, injection site pain, edema

Uncommon: Anemia, dizziness, pruritus, increased liver enzymes, hypertension

Rare: Gastric ulcers, GI bleeding, asthma, visual disorders, mood changes

Very rare: Agranulocytosis, hepatitis, Stevens-Johnson syndrome, renal failure

Unknown: Infertility, photosensitivity, pancreatitis

Pregnancy and Breastfeeding

Contraindicated in the 3rd trimester of pregnancy

Not recommended during breastfeeding

May impair female fertility

Storage Conditions

Store below 30°C

Keep in the original carton to protect from light

Use only clear, particle-free solution

For single use only; discard opened ampoules

Packaging

Carton box with 3 or 6 transparent glass ampoules of 3 ml each, with a package insert.