Adolor 15 mg/1 ml 3 ampoules

Adolor 15 mg/1 ml 3 ampoules

Composition:

Ketorolac tromethamine — 15 mg (per 1 ml ampoule).
Excipients:
Sodium chloride, Benzyl alcohol, Ethanol 96%, Water for injections.

Product Description:

Adolor is a non‑steroidal anti‑inflammatory drug (NSAID) with strong analgesic properties.
It also has anti‑inflammatory and moderate antipyretic effects.
The mechanism of action is associated with non‑selective inhibition of COX‑1 and COX‑2 enzymes, mainly in peripheral tissues, resulting in suppression of prostaglandin biosynthesis — mediators of pain sensitivity, inflammation, and thermoregulation.
Ketorolac is a racemic mixture of R(+) and S(–) enantiomers, with the analgesic effect attributed to the S(–) enantiomer.
It does not act on opioid receptors, does not depress respiration, does not cause drug dependence, and has no sedative or anxiolytic effects. Its analgesic efficacy is comparable to morphine and significantly exceeds other NSAIDs.

Indications for use:

• Moderate to severe pain: trauma, dental pain, postoperative pain, oncological diseases.
• Myalgia, arthralgia, neuralgia, radiculitis.
• Dislocations, sprains.
• Rheumatic diseases.
• Intended for symptomatic therapy to reduce pain and inflammation; does not affect disease progression.

Method of administration and dosage:

• Administer intravenously or intramuscularly.
• Inject deeply into the muscle, slowly (or intravenously by bolus injection) over at least 15 seconds, using the minimum effective dose for the shortest possible course.
• Single dose: 
  Adults under 65 years — 10–30 mg depending on pain severity; 
  elderly patients over 65 years or with renal impairment — 10–15 mg.
• Multiple doses: 
  Adults under 65 years and children over 16 years — 10–60 mg initially, then 10–30 mg every 6 hours (typically 30 mg);
  elderly patients over 65 years or with renal impairment — 10–15 mg every 4–6 hours.
• Course duration for parenteral administration must not exceed 5 days.

Contraindications:

• History of erosive or ulcerative gastrointestinal lesions.
• Renal impairment (serum creatinine > 442 µmol/L).
• Hypovolemia, dehydration.
• Bronchial asthma, bronchospasm.
• Coagulation disorders, high risk of bleeding.
• Postoperative bleeding, gastrointestinal or intracranial bleeding.
• Pregnancy, lactation.
• Children under 16 years.
• Hypersensitivity to ketorolac or other NSAIDs.

Precautions:

Use with caution in elderly patients,
those with hepatic or renal impairment,
chronic heart failure,
arterial hypertension,
bronchial asthma,
or bronchial obstruction.
Caution is advised during activities requiring increased attention and rapid psychomotor responses.

Side effects:

• Digestive system: dyspepsia, nausea, epigastric pain; rarely — flatulence, belching, vomiting, constipation, erosive/ulcerative GI lesions, hepatic dysfunction.
• Central nervous system: headache, dizziness, drowsiness, insomnia, depression.
• Urinary system: frequent urination, oliguria, hematuria.
• Coagulation system: hematomas, postoperative bleeding, nosebleeds, prolonged bleeding time.
• Allergic reactions: skin itching, urticaria, laryngeal edema, bronchospasm.

Pregnancy and lactation:

Contraindicated during pregnancy and breastfeeding.

Storage conditions:

Store at temperatures not exceeding 30 °C.

Packaging:

Carton box contains 3 ampoules of 1 ml and an instruction leaflet.