Torseretic

Composition:

Each tablet contains:

Torasemide 5 mg

Auxiliary components: microcrystalline cellulose, lactose monohydrate, povidone, sodium carboxymethyl starch (sodium starch glycolate), magnesium stearate

Properties:

“Loop” diuretic. The main mechanism of action is due to the reversible binding of torasemide to the sodium / chlorine / potassium counterporter located in the apical membrane of the thick segment of the ascending loop of Henle, as a result of this, the reabsorption of sodium ions is reduced or completely inhibited and the osmotic pressure of the intracellular fluid and water reabsorption decrease.

Torasemide, to a lesser extent than furosemide, causes hypokalemia, while it is more active and its effect is longer. The diuretic effect develops within about an hour after oral administration, reaching a maximum after 3-6 hours, and lasts from 8 to 10 hours.

Reduces systolic and diastolic blood pressu while lying and standing.

Indications:

Edema syndrome of various origins, incl. with chronic heart failure, liver and kidney diseases.

Arterial hypertension.

Method of administration and dosage:

The drug is taken orally once a day after meals with a small amount of water.

Edema syndrome of various origins, incl. with chronic heart failure, diseases of the liver, lungs and kidneys.

The therapeutic dose is 5 mg once a day. If necessary, the dose should be gradually increased to 20-40 mg once a day. The maximum single dose is 40 mg, it is not recommended to exceed it (there is no experience of use). The drug is prescribed for a long period or until the edema disappears.

Arterial hypertension

The initial dose is 2.5 mg (1/2 tablet with a dosage of 5 mg) once a day. If necessary, the dose can be increased to 5-10 mg once a day.

Anuria; hepatic coma and precoma; refractory hypokalemia; refractory hyponatremia; dehydration; pronounced violations of the outflow of urine of any etiology (including unilateral urinary tract damage); glycosidic intoxication; acute glomerulonephritis; sinoatrial and AV-blockade Il and Ill degree; children and adolescents up to 18 years old; pregnancy; hypersensitivity to torasemide; allergy to sulfonamides (sulfonamide antimicrobials or sulfonylureas).

Precautions:

With long-term treatment with torasemide, it is recommended to regularly monitor the electrolyte balance (especially the level of potassium), glucose, uric acid, creatinine, lipids and cellular components of the blood. For patients receiving high doses of torasemide, in order to avoid the development of hyponatremia and metabolic alkalosis, it is inappropriate to limit the consumption of table salt. The risk of hypokalemia is greatest in patients with cirrhosis of the liver, severe diuresis, inadequate intake of electrolytes from food, and also with concomitant treatment with corticosteroids or ACTH.

Side effects:

From the side of metabolism: infrequently hypercholesterolemia, hypertriglyceridemia, polydipsia.

From the nervous system: often – dizziness, headache, drowsiness; infrequently – muscle cramps of the lower extremities; the frequency is unknown – confusion, fainting, paresthesia in the limbs.

From the side of the cardiovascular system: infrequently – extrasystole, tachycardia, increased heart rate, facial flushing; frequency unknown – excessive arterial hypotension, deep vein thrombosis, thromboembolism, hypovolemia.

From the respiratory system: infrequently nosebleeds.

From the digestive system: often – diarrhea; infrequently – abdominal pain, flatulence; the frequency is unknown – nausea, vomiting, loss of appetite, pancreatitis, dyspeptic symptoms.

On the part of the kidneys and urinary tract: often – an increase in the frequency of urination, polyuria, nocturia.

Storage method:

At a temperature not higher than 30 degrees. In a dry place.

Packaging:

The cardboard box holds 1, 2 or 3 blisters of 10 tablets.