Tradename:

Tamoxifen

Tamoxifen

Composition:

Each tablet contains:

Tamoxifen 10 mg

Ciprofloxacin  500mg

Auxiliary components:

corn starch, lactose monohydrate, povidone K30, magnesium stearate, sodium starch glycolate.

Properties:

Antineoplastic agent. Antiestrogen. Blocks estrogen receptors and thus inhibits the progression of estrogen-stimulated neoplastic disease.

Indications:

• breast cancer treatment
• treatment of anovulatory infertility

Method of administration and dosage:

Breast cancer

Adults:

The usual recommended daily dose of tamoxifen is 20 mg. With higher doses, there is an additional benefit in the form of a later

development of relapse or an improvement in patient survival. Data supporting the use of 30-40 mg per day for treatment are not available, despite the fact that they have been used to treat patients with more extensive diseases.

Elderly patients:

A similar dosing regimen was used in elderly patients with breast cancer, and in some patients as monotherapy.

Anovulatory infertility.

Before prescribing a course of therapy, initiating or subsequent, it is necessary to exclude a possible pregnancy. For women with a regular but anovulatory menstrual cycle, the initiation dose is 20 mg per day, given on the 2nd, 3rd, 4th and 5th day of the menstrual cycle. In case of unsatisfactory basal temperature or insufficiency of pre-ovulatory cervical mucus, a subsequent course of treatment may be prescribed during further menstrual cycles with an increase in the do to 40, and then to 80 mg per day.

In women with regular menstrual cycles, treatment initiation may occur on any day of the cycle. In the absence of signs of ovulation, the subsequent course of treatment can be started 45 days after the completion of the previous treatment with an increase in the dose as described above.

Contraindications:

Thrombophlebitis, pregnancy, hypersensitivity to tamoxifen.

Precautions:

Use with caution in leukopenia, thrombocytopenia, hypercalcemia, in patients with cataracts, hyperlipidemia.

During treatment, you should regularly monitor the picture of peripheral blood (especially the number of platelets); blood calcium and glucose levels; with prolonged use, observation by an ophthalmologist is indicated (every 3 months).

Should not be combined with preparations containing hormones, especially estrogens.

With simultaneous use with drugs that affect the blood coagulation system, a dose adjustment of tamoxifen is necessary.

In experimental studies, the carcinogenic effect of tamoxifen has been established.

Side effects:

From the digestive system: nausea, vomiting, increased activity of hepatic transaminases; in some cases – fatty liver, cholestasis, hepatitis.

From the side of the central nervous system: rarely – depression, dizziness, headache, retrobulbar neuritis.

From the side of the organ of vision: rarely retinopathy, keratopathy, cataract.

From the hematopoietic system: rarely thrombocytopenia, leukopenia.

From the endocrine system: in women endometrial hyperplasia, vaginal bleeding, flashes, weight gain; in men – impotence, decreased libido.

From the side of the cardiovascular system: edema, thromboembolism, phlebitis.

Dermatological reactions: alopecia, rash, itching.

Others: pain in bones and lesions, fever.

Storage method:

At a temperature not higher than 30 degrees. In a dry place.

Packaging:

The cardboard box contains:

Tamoxifen 10 mg 30 tablets, paper instructions.