Suprax 400 mg 5 capsules

Suprax 400 mg 5 capsules

Composition

Each capsule contains:

Cefixime 400 mg

Properties

Semi-synthetic cephalosporin antibiotic of the third generation for oral administration with a wide spectrum of action. It has a bactericidal effect. The mechanism of action is due to the inhibition of the synthesis of the cell membrane of the pathogen. Cefixime is resistant to beta-lactamases produced by most gram-positive and gram-negative bacteria.

In vitro cefixime is active against gram-positive bacteria: Streptococcus agalactiae; gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus, Serratia marcescens.

In vitro and in clinical practice, cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes; gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae.

Pseudomonas spp., Enterococcus (Streptococcus) serogroup D, Listeria monocytogenes, most Staphylococcus spp. are resistant to cefixime (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.

Indications

Infectious and inflammatory diseases caused by sensitive microorganisms: pharyngitis, tonsillitis, sinusitis, acute and chronic bronchitis, otitis media, uncomplicated urinary tract infections, uncomplicated gonorrhea.

Method of Administration and Dosage

For adults and children over 12 years old with a body weight of more than 50 kg, the daily dose is 400 mg (1 time / day or 200 mg 2 times / day). The duration of the course of treatment is 7-14 days. For uncomplicated gonorrhea, 400 mg once.

Children under the age of 12 - 8 mg / kg of body weight 1 time / day or 4 mg / kg every 12 hours.

For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days.

In case of impaired renal function (with CC from 21 to 60 ml / min) or in patients on hemodialysis, the daily dose should be reduced by 25%.

Contraindications

Hypersensitivity to cephalosporins and penicillins.

Precautions

It should be used with caution in elderly patients, patients with chronic renal failure or pseudomembranous colitis (in history), and in children under 6 months of age.

With prolonged use, it is possible to disrupt the normal intestinal microflora, which can lead to the growth of Clostridium difficile and the development of severe diarrhea and pseudomembranous colitis.

In patients with a history of allergic reactions to penicillins, hypersensitivity to cephalosporin antibiotics is possible.

During treatment, a positive direct Coombs' reaction and a false positive urine glucose reaction are possible.

Side Effects

From the digestive system: dry mouth, anorexia, diarrhea, nausea, vomiting, abdominal pain, flatulence, transient increase in the activity of hepatic transaminases and alkaline phosphatase, hyperbilirubinemia, jaundice, gastrointestinal candidiasis, dysbiosis; rarely - stomatitis, glossitis, pseudomembranous enterocolitis.

From the hematopoietic system: leukopenia, thrombocytopenia, neutropenia, hemolytic anemia.

From the central nervous system: dizziness, headache.

From the urinary system: interstitial nephritis.

Allergic reactions: pruritus, urticaria, flushing of the skin, eosinophilia, fever.

Storage Method

At a temperature not higher than 30 degrees.

Packaging

The cardboard box contains a blister of 5 capsules and a package insert.