Clindam 300 mg 16 capsules

Trade name:

Clindam

Compound:

Each capsule contains:

Clindamycin (as clindamycin hydrochloride) 300 mg

Auxiliary components:

Lactose monohydrate, magnesium stearate, talc, starch, gelatin, titanium dioxide.

Properties:

Clindamycin is a drug from the group of antibiotics – lincosamides, has a wide spectrum of action, bacteriostatic, binds to the 50S subunit of the ribosome and inhibits protein synthesis in microorganisms. Active against Staphylococcus spp. (including Staphylococcus epidermidis producing penicillinase), Streptococcus spp. (excluding Enterococcus spp.), Streptococcus pneumoniae, anaerobic and microaerophilic Gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.), Corynebacterium diphtheriae, Clostridium perfringens, Clostridium tetani, Mycoplasma spp., Bacteroides spp. (including Bacteroides fragilis and Bacteroides melaninogenicus), anaerobic Gram-positive, non-sporeforming bacilli (including Propionibacterium spp., Eubacterium spp., Actinomyces spp.).

Most strains of Clostridium perfringens are sensitive to clindamycin, but other types of Clostridium (Clostridium sporogenes, Clostridium tertium) are resistant to the drug, therefore, in infections caused by Clostridium spp., it is recommended to determine the antibiogram.

According to the mechanism of action and antimicrobial spectrum, it is close to lincomycin (in relation to some types of microorganisms, especially bacteroids and non-spore-forming anaerobes, it is 2-10 times more active).

Indications:

– infectious and inflammatory diseases caused by microorganisms sensitive to clindamycin;

– infections of the upper respiratory tract and infections of the ENT organs (pharyngitis, tonsillitis, sinusitis, otitis), lower respiratory tract (pneumonia, including aspiration, lung abscess, pleural empyema, bronchitis), scarlet fever, diphtheria;

– infections of the urogenital tract (chlamydia, endometritis, vaginal infections, tubo-ovarian inflammation);

– infections of the skin and soft tissues (infected wounds, abscesses, boils, panaritium), abdominal cavity (peritonitis, abscess), oral cavity;

– acute and chronic osteomyelitis;

– septicemia (primarily anaerobic);

– bacterial endocarditis;

– prevention of peritonitis and intra-abdominal abscesses after intestinal perforation or as a result of traumatic infection (in combination with aminoglycosides).

Dosage and administration:

The drug is taken, preferably at the same time as a meal. To avoid irritation of the esophageal mucosa, the capsules should be taken with a full glass of water.

Adults: 600 mg to 1800 mg per day in 2, 3 or 4 divided doses.

Children over 6 years: 8-25 mg / kg / day in 3 or 4 divided doses.

Contraindications:

– hypersensitivity to clindamycin and lincomycin or to any of the excipients of the drug;

– diseases of the gastrointestinal tract, especially ulcerative colitis, regional enteritis or colitis associated with taking antibiotics;

– severe liver dysfunction;

– severe impairment of kidney function;

– pregnancy;

– breast-feeding.

Precautionary measures:

Clindamycin should be used with caution in patients with bronchial asthma, gastrointestinal diseases, especially colitis, history, atopy, hypersensitivity to drugs.

Side effects:

From the digestive system: abdominal pain, nausea, diarrhea, vomiting, esophagitis, pseudomembranous enterocolitis, dysbacteriosis, esophageal ulcers.

On the part of the hematopoietic organs: leukopenia, neutropenia, agranulocytosis, thrombocytopenia, eosinophilia, thrombocytopenic purpura.

On the part of the skin: papular rash, urticaria, exfoliative dermatitis, bullous dermatitis;

From the liver and biliary tract: hepatotoxicity, hyperbilirubinemia, jaundice.

From the immune system: hypersensitivity reactions, such as angioedema and anaphylaxis, as a rule, in patients allergic to penicillin; DRESS syndrome (a syndrome characterized by a combination of rash, fever, eosinophilia and symptoms of damage to internal organs).

From the musculoskeletal system: polyarthritis.

Infections and invasions: the development of superinfections, vaginitis.

Storage method:

Store at a temperature not exceeding 30 degrees.

Package:

Cardboard box contains 2 blisters of 8 tablets, paper instructions.