Ketolac 10 mg 20 tablets

Ketolac

Each tablet contains:

Ketorolac tromethamine 10 mg

Auxiliary components:

Calcium phosphate dibasic, microcrystalline cellulose, crospovidone, magnesium stearate, ethanol.

Ketorolac is an NSAID that has a pronounced analgesic (analgesic) effect, also has an anti-inflammatory and moderate antipyretic effect.

The mechanism of action is associated with non-selective inhibition of the activity of the enzymes COX-1 and COX-2, mainly in peripheral tissues, which results in inhibition of the biosynthesis of prostaglandins – modulators of pain sensitivity, inflammation and thermoregulation. Ketorolac is a racemic mixture of R (+) and S (-) – enantiomers, while the analgesic (analgesic) effect is due to the S (-) – enantiomer.

Ketorolac does not affect opioid receptors, does not depress respiration, does not cause drug dependence, does not have a sedative and anxiolytic effect.

The strength of the analgesic (pain-relieving) effect is comparable to that of morphine, significantly superior to other NSAIDs.

After oral administration, the onset of the analgesic (analgesic) action is noted, respectively, after 1 hour, the maximum effect is achieved after 2-3 hours.

– pain syndrome of strong and moderate severity: trauma, toothache, pain in the postoperative period, cancer, myalgia, arthralgia, neuralgia, sciatica, dislocations, sprains, rheumatic diseases.

Designed for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

The drug should be administered orally once or repeatedly, depending on the severity of the pain syndrome.

A single dose – 10 mg, with repeated administration, it is recommended to take 10 mg up to 4 times / day, depending on the severity of the pain. The maximum daily dose should not exceed 40 mg.

When taken orally, the duration of the course should not exceed 5 days.

– complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including in history);

– urticaria, rhinitis caused by taking NSAIDs (in history);

– intolerance to drugs of the pyrazolone series;

– dehydration, hypovolemia (regardless of the cause that caused it);

– bleeding or high risk of their development;

– condition after coronary artery bypass grafting;

-confirmed hyperkalemia;

-inflammatory bowel disease;

– erosive and ulcerative lesions of the gastrointestinal tract in the acute stage, peptic ulcers;

-hypocoagulation (including hemophilia);

– severe renal failure (CC less than 30 ml / min);

– severe liver failure or active liver disease;

– hemorrhagic stroke (confirmed or suspected);

– hemorrhagic diathesis;

– violation of hematopoiesis;

-pregnancy;

– childbirth;

-period of lactation (breastfeeding);

– children under 16 years of age (efficacy and safety have not been established);

-increased sensitivity to ketorolac and other NSAIDs.

When used together with other NSAIDs, fluid retention, cardiac decompensation, arterial hypertension can be observed.

To reduce the risk of developing NSAID gastropathy, antacids, misoprostol, omeprazole are prescribed.

On the part of the digestive system: often (especially in elderly patients over 65 years of age with a history of erosive and ulcerative lesions of the gastrointestinal tract) – gastralgia, diarrhea.

From the side of the central nervous system and peripheral nervous system: often – headache, dizziness, drowsiness.

Others: often – edema (including of the face, legs, ankles, fingers, feet), weight gain; less often – increased sweating; rarely – swelling of the tongue, fever.

Store at a temperature not exceeding 30 degrees.

The cardboard box contains 2 blisters of 10 tablets and paper instructions.