Duricef 1 g 8 tablets

Tradename:

Duricef

Composition:

Each tablet contains:

Cefadroxil 1 g

Auxiliary components:

Magnesium stearate, microcrystalline cellulose.

Properties:

Cephalosporin antibiotic of the 1st generation with a broad spectrum of action for oral administration. Has a bactericidal effect.

Active against gram-positive bacteria: Staphylococcus spp. (strains producing and not producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; gram-negative bacteria: Shigella spp., Salmonella spp., Haemophilus influenzae, Escherichia coli, Klebsiella spp., some strains of Proteus spp.

Indications:

Infectious and inflammatory diseases cause by microorganisms sensitive to cefadroxil,

including: diseases of the urinary tract, upper and lower respiratory tract, skin, soft tissues, bones.

Method of administration and dosage:

Set individually, taking into account the severity of the course and localization of the infection, the sensitivity of the pathogen. When taken orally in adults and children weighing more than 40 kg, it is used in an average dose of 1-2 g / day in 1-2 doses. Children weighing less than 40 kg – 25-50 mg

/ kg / day (preferably in the form of a suspension) in 1-2 doses. The course of treatment is 7-14 days. The minimum duration of treatment for infectious and inflammatory diseases caused by group A beta-hemolytic streptococcus is 10 days.

Contraindications:

Hypersensitivity to cephalosporins.

The drug should be used with caution in newborns and premature babies, with chronic renal failure, bleeding and gastrointestinal diseases (including a history of NUC), durin pregnancy and lactation, in debilitated and malnourished patients.

Precautions:

Patients with a history of allergic reactions to penicillins may have hypersensitivity to cephalosporin antibiotics.

During treatment, it is necessary to monitor kidney function, especially in patients receiving the drug in high doses.

Treatment is continued for 48-72 hours after symptoms disappear; in case of infections caused by Streptococcus pyogenes, the course of treatment is at least 7-10 days.

During treatment, a false positive direct Coombs’ reaction and a false positive urine glucose reaction are possible.

Side effects:

Allergic reactions: chills, rash, itching, urticaria, rarely – exudative erythema multiforme, bronchospasm, malignant exudative erythema (Stevens-Johnson syndrome), anaphylactic shock.

From the digestive system: diarrhea, nausea, vomitinq or constipation, flatulence, abdominal

cramps and pain, ulceration of the oral mucosa, oral candidiasis, glossitis, pseudomembranous enterocolitis, liver dysfunction (increased activity of AST, ALT, ALP, LDH, bilirubin), cholestasis.

From the urinary system: impaired renal function, dysuria.

From the reproductive system: itching in the perineum, vaginitis.

From the side of the central nervous system: convulsions.

From the senses: hearing loss.

On the part of the hematopoietic system: a decrease in the concentration of hemoglobin and hematocrit, anemia (aplastic or hemolytic), eosinophilia, neutropenia, leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia, prolongation of prothrombin time.

Local reactions: irritation, infiltration and pal at the injection site, phlebitis.

Storage method:

At a temperature not higher than 30 degrees. Store in a cool dry place.

Packaging:

The cardboard box holds 8 tablets.