Doxymycin 100 mg 10 capsules

Doxymycin 100 mg 10 capsules

Composition:

Active Ingredient: Doxycycline — 100 mg per capsule.
Excipients: Calcium stearate, lactose monohydrate, potato starch.

Product Description:

• Broad-spectrum bacteriostatic antibiotic belonging to the semi-synthetic tetracycline class, formulated as hard capsules.
• The drug penetrates intracellularly to act on intracellular pathogens. 
• It suppresses protein synthesis in microbial cells by disrupting the binding of transport aminoacyl-tRNA to the 30S subunit of the ribosomal membrane. 
• Compared to natural tetracyclines, it exhibits higher therapeutic efficacy (effective at tenfold lower doses), a longer duration of action, and complete absorption while causing less suppression of intestinal flora. 
• Cross-resistance exists to other tetracyclines as well as penicillins.

Indications for Use:

• Infectious and inflammatory diseases caused by doxycycline-sensitive pathogens:
• Upper and lower respiratory tract and ENT infections;
• Genitourinary system and pelvic infections;
• Gastrointestinal and biliary tract infections;
• Skin, soft tissue, and odontogenic infections;
• Severe and specific infections (including typhus, brucellosis, rickettsial diseases, chlamydial infections, mycoplasmosis, Lyme disease/borreliosis).

Method of Administration and Dosage:

• How to use: Oral administration, during or immediately after meals in the daytime, with an ample amount of fluid (may be taken with milk or carbonated beverages).
• Standard dosing regimen for adults and adolescents over 12 years (weighing over 45 kg):
  Day 1: 200 mg per day (as a single dose or 100 mg every 12 hours).
  Subsequent days (maintenance dose): 100 mg per day (as a single dose or 50 mg every 12 hours).
• Severe or chronic infections (e.g., chronic urinary tract infections): 200 mg per day throughout the entire course of treatment.

Contraindications:

• Known hypersensitivity to doxycycline, other tetracyclines, or any inactive excipients
• Severe hepatic impairment
• Porphyria and leukopenia
• Lactase deficiency, lactose intolerance, glucose-galactose malabsorption
• Children under 12 years of age, as well as children over 12 years weighing under 45 kg (due to the risk of insoluble calcium complex formation depositing in bone skeleton, enamel, and dentin)

Precautions:

To prevent local mucosal irritation (esophagitis, gastritis, gastrointestinal ulceration), take during daytime hours with plenty of fluids and food.
Due to the risk of photosensitization, limit exposure to direct sunlight and UV radiation during treatment and for 4–5 days thereafter.
Regular monitoring of blood counts, liver, and kidney function is recommended during long-term therapy.

Adverse Reactions / Side Effects:

• Gastrointestinal System: Nausea, vomiting, abdominal pain, constipation or diarrhea, glossitis, dysphagia, esophagitis (including erosive), gastritis, gastric and duodenal ulceration, pseudomembranous colitis, enterocolitis.
• Allergic & Dermatological Reactions: Maculopapular rash, skin itching, skin hyperemia, angioedema, anaphylactoid reactions, drug-induced lupus erythematosus, erythematous rash, exfoliative dermatitis, urticaria, anaphylaxis, anaphylactic shock, Stevens-Johnson syndrome.
• Cardiovascular System: Pericarditis, hypotension (decreased blood pressure), tachycardia, erythema multiforme.
• Hematologic Organs: Hemolytic anemia, thrombocytopenia, neutropenia, leukopenia, eosinophilia, decreased prothrombin index.
• Hepatobiliary System: Liver dysfunction, elevated liver transaminases, autoimmune hepatitis, cholestasis.
• Musculoskeletal System: Arthralgia, myalgia.

Pregnancy and Lactation:

Contraindicated during pregnancy (doxycycline impairs fetal bone and tooth development) and lactation (breastfeeding must be discontinued if treatment is required).

Storage Conditions:

Store at a temperature not exceeding 25 °C in a dry place.
Keep out of reach of children.

Packaging:

Cardboard box containing a blister of 10 capsules.