Ciprodiazole 500/500 mg 20 tablets

Trade name:

Cyprodiazole

Ciprodiazole

Compound:

Each tablet contains:

Ciprofloxacin 500 mg

Metronidazole 500 mg

Auxiliary components:

Starch, sodium glyconate, povidone K30, lactose monohydrate 200, sodium lauryl sulfate, magnesium stearate, green vincoate.

Properties:

Due to the constituent components.

Gram-negative aerobic bacteria are sensitive to Ciprofloxacin and Gram-positive aerobic bacteria are also sensitive.

Acts bactericidal. The component inhibits the bacterial DNA-gyrase enzyme, as a result of which DNA replication and the synthesis of bacterial cell proteins are disrupted. Ciprofloxacin acts both on multiplying microorganisms and on those in the resting phase.

Metronidazole is active against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis. Giardia intestinalis, Lamblia spp., and obligate anaerobes Bacteroidcs spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacleroides vulgatus), Fusobacterium spp., Veillonela spp., Prevotella (P.bivia, P.buccae, P.disiens), and some Gram-positive microorganisms ( Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). The minimum inhibitory concentration for these strains is 0.125-6.25 µg/ml. In combination with amoxicillin, it is active against Helicobacter pylori (amoxicillin inhibits the development of resistance to metronidazole).

Indications:

Infectious and inflammatory diseases caused by microorganisms sensitive to Ciprofloxacin and Metronidazole.

Dosage and administration:

Adults:

The recommended dose is 1 tablet every 12 hours.

Contraindications:

deficiency of glucose-6-phosphate dehydrogenase;

pseudomembranous colitis;

children’s age (up to 18 years – completion of the process of skeleton formation);

pregnancy;

lactation period;

organic lesions of the central nervous system (including epilepsy);

liver failure (in the case of high doses);

increased sensitivity.

Precautionary measures:

During the treatment period, ethanol is contraindicated (possible development of a disulfiram-like reaction: spastic abdominal pain, nausea, vomiting, headache, sudden rush of blood to the face).

With prolonged therapy, it is necessary to control the blood picture.

If severe and prolonged diarrhea occurs during or after treatment with the drug, the diagnosis of pseudomembranous colitis should be excluded, which requires immediate discontinuation of the drug and the appointment of appropriate treatment.

If pain occurs in the tendons or when the first signs of tendovaginitis appear, treatment should be discontinued.

During the period of treatment with the drug, it is necessary to provide a sufficient amount of fluid while maintaining normal diuresis.

Side effects:

On the part of the digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, anorexia, cholestatic jaundice (especially in patients with previous liver diseases), hepatitis, hepatonecrosis.

From the nervous system: dizziness, headache, fatigue, anxiety.

Allergic reactions: skin itching, urticaria, blistering, accompanied by bleeding.

Storage:

Store at a temperature not exceeding 30 degrees.

Package:

The cardboard box contains 20 tablets and paper instructions.

Manufacturer:

Minapharma, Egypt