Buspar 10 mg 20 tablets

Tradename:

Buspar

Buspar

Structure:

Each tablet contains:

10mg buspirone hydrochloride

Auxiliary components:

lactose monohydrate, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate, colloidal anhydrous silicon dioxide.

Properties:

Anxiolytic drug (tranquilizer) of the non-benzodiazepine series also has an antidepressant effect. Unlike classical anxiolytics, it does not have antiepileptic, sedative, hypnotic and muscle relaxant effects.

The mechanism of action is associated with the effect of buspirone on the serotonergic and dopaminergic systems. Selectively blocks presynaptic dopamine receptors and increases the rate of excitation of dopamine neurons in the midbrain. In addition, buspirone is a selective partial agonist of 5-HT1A serotonin receptors. Buspirone has no significant effect on benzodiazepine receptors and does not affect the binding of GABA, does not have a negative effect on psychomotor functions, does not cause tolerance, drug dependence and withdrawal syndrome. Does not potentiate the effects of alcohol. In terms of anxiolytic activity, buspirone is approximately equal to benzodiazepines.

Indications:

generalized anxiety disorder (GAD);

adjuvant therapy for depressive disorders (the drug is not prescribed for depression monotherapy).

Method of administration and dosage:

The drug should always be taken at the same time of the day, before or after meals, in order to avoid significant fluctuations in the concentration of the active substance in the blood plasma throughout the day.

The drug should not be taken sporadically to treat anxiety, since the therapeutic effect of the drug develops only after repeated administration and does not appear earlier than after 7-14 days of treatment.

The dose should be selected individually.

The recommended dose is 15-30 mg per day. The daily dose should be divided into 2-3 doses.

Contraindications:

-increased sensitivity to the components of the drug;

– severe renal failure (GFR <10 ml / min);

– severe hepatic impairment (prothrombin time> 18 sec);

-glaucoma;

-myasthenia gravis;

-period of lactation (breastfeeding);

pregnancy or suspected pregnancy.

Precautions:

Buspirone does not cause addiction to the drug, however, its administration to patients with an established or suspected predisposition to drug dependence requires careful medical supervision.

Since the anxiolytic effect appears after 7-14 days of taking the drug, and the full therapeutic effect develops in about 4 weeks, patients with severe anxiety need careful medical supervision during the initial period of therapy.

Side effects:

From the side of the cardiovascular system: often – chest pain;

From the nervous system: often – dizziness, headache, increased nervous irritability, sleep disturbances.

From the senses: often – tinnitus.

Others: weight gain, fever, weight loss; rarely – alcohol abuse, loss of voice, tinnitus, hiccups.

Storage method:

In a dry, dark place at a temperature not exceeding 30 degrees.

Packaging:

The cardboard box contains 2 blisters of 10 tablets.