Amrizol 250 mg 20 tablets

Amrizole

Amrizol

Each tablet contains:

Metronidazole 250mg

Auxiliary components:

Dibasic calcium phosphate, starch, povidone K25, magnesium stearate, colium, silicone dioxide.

Antiprotozoal and antimicrobial drug derived from 5-nitroimidazole. The mechanism of action consists in the biochemical reduction of the 5-nitro group by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

Infections caused by anaerobic pathogens: wound infection, infection of the respiratory system, urinary tract, intestines; prevention of anaerobic infection before bowel surgery; trichomoniasis, amebiasis, giardiasis, Crohn’s disease.

Inside, during or after meals, without chewing.

The course of treatment is determined by the doctor after the tests: On average, the course of treatment: Children 2-5 years old – 250 mg / day; 5-10 years old – 250-375 mg / day, children 10-15 years old 500 mg / day and adults – 500 mg 2-3 times a day. The course of treatment is 5-10 days.

In case of severe renal impairment (CC less than 10 ml / min), the daily dose should be halved.

-leukopenia (including history);

-organic lesions of the central nervous system (including epilepsy);

-hepatic failure (in the case of large doses);

-pregnancy (I trimester);

– lactation period;

-increased sensitivity.

With caution – pregnancy (II, III trimesters), renal / hepatic failure.

During the period of treatment, ethanol is contraindicated (a disulfiram-like reaction may develop: spastic abdominal pain, nausea, vomiting, headache, sudden flush of blood to the face).

In combination with amoxicillin, it is not recommended for use in patients under 18 years of age.

With prolonged therapy, it is necessary to control the blood picture.

With leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process.

The appearance of ataxia, dizziness and any other deterioration in the neurological status of patients requires discontinuation of treatment.

May immobilize treponemas and lead to false positive Nelson’s test.

Stains urine dark.

When treating Trichomonas vaginitis in women and Trichomonas urethritis in men, it is necessary to abstain from sexual activity. Simultaneous treatment of sexual partners is mandatory. Treatment does not stop during menstruation. After trichomoniasis therapy, control tests should be carried out for three successive cycles before and after menstruation.

After treatment of giardiasis, if symptoms persist, after 3-4 weeks, conduct 3 fecal analyzes at intervals of several days (in some successfully treated patients, lactose intolerance caused by invasion may persist for several weeks or months, resembling the symptoms of giardiasis).

From the digestive system: diarrhea, anorexia, nausea, vomiting, intestinal colic, constipation, metallic taste in the mouth, dry mouth, glossitis, stomatitis, pancreatitis.

From the nervous system: dizziness, impaired coordination of movements, ataxia, confusion, irritability, depression, irritability, weakness, insomnia, headache, convulsions, hallucinations, peripheral neuropathy.

Allergic reactions: urticaria, skin rash, skin flushing, nasal congestion, fever, arthralgia.

From the genitourinary system: dysuria, cystitis, polyuria, urinary incontinence, candidiasis, red-brown urine staining.

Others: neutropenia, leukopenia, flattening of the T wave on the ECG.

In a cool dry place at a temperature not exceeding 30 degrees.

Cardboard box holds 2 blisters of 10 tablets