Tradename:

E-Moxiclav

E-Moxclav

Composition:

Each tablet contains:

Amoxicillin 875 mg

Clavulanic acid 125 mg

Auxiliary components:

microcrystalline cellulose, sodium carboxymethyl starch, colloidal silicon dioxide, magnesium stearate, white opadry, hypromellose, macrogol, titanium dioxide.

Properties:

Combined preparation of amoxicillin and clavulanic acid – a beta-lactamase inhibitor. Acts bactericidal, inhibits the synthesis of t bacterial wall.

Active against aerobic gram-positive bacteria (including strains producing beta-lactamase): Staphylococcus aureus; aerobic gram-negative bacteria: Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp.,

Moraxella catarrhalis. The following pathogens are sensitive only in vitro: Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus anthracis, Streptococcus pneumoniae, Streptococcus viridans,

Enterococcus faecalis, Corynebacterium spp., Listeria monocytogenes; anaerobic Clostridium spp., Peptococcus spp., Peptostreptococcus spp .; as well as aerobic gram-negative bacteria (including strains producing betalactamases): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp., Bordetella pertussis, Yersinia enterocolitica,

Gardnerella vaginalis, Neisseria meningitidis,

Neisseria gonorrhoeae, Haemophilus ducreyi,

Yersinia multocida (formerly Pasteurella),

Campylobacter jejuni; anaerobic gram-negative bacteria (including strains producing betalactamases): Bacteroides spp., including Bacteroides fragilis.

Clavulanic acid inhibits types Il, Ill, IV and V beta-lactamases, is inactive against type I beta-lactamases produced by Pseudomonas

aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high tropism for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases.

Indications:

Treatment of infectious and inflammatory diseases caused by sensitive pathogens: lower respiratory tract infections (bronchitis, pneumonia, pleural empyema, lung abscess); ENT infections (sinusitis, tonsillitis, otitis media); infections of the genitourinary system and pelvic organs (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingo-oophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, septic abortion, postpartum sepsis, pelvioperitonitis, soft chancre); infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, abscess, phlegmon, wound infection); osteomyelitis; postoperative infections. Prevention of infections in surgery.

Method of administration and dosage:

Adults and children over 12 years old or weighing 40 kg or more: 500 mg 2 times / day

or 250 mg 3 times / day. For severe infections and respiratory tract infections – 875 mg 2 times / day or 500 mg 3 times / day.

The maximum daily dose of amoxicillin for adults and children over 12 years old is 6 g, for children under 12 years old – 45 mg / kg body weight.

The maximum daily dose of clavulanic acid for adults and children over 12 years old is 600 mg, for children under 12 years old – 10 mg / kg body weight.

In case of difficulty in swallowing in adults, the use of a suspension is recommended.

Duration of treatment – up to 14 days, acute otitis media – up to 10 days.

Contraindications:

Hypersensitivity to the components of the drug (including cephalosporins and other betalactam antibiotics); infectious mononucleosis (including when a measles-like rash appear phenylketonuria; episodes of jaundice or abnormal liver function as a result of

amoxicillin / clavulanic acid use in history; CC less than 30 ml / min (for tablets 875 mg / 125 mg).

Carefully:

Pregnancy, lactation, severe hepatic failure, gastrointestinal diseases (including a history of colitis associated with the use of penicillins), chronic renal failure.

Precautions:

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken with meals.

The development of superinfection is possible due to the growth of microflora insensitive to it, which requires a corresponding change in antibacterial therapy.

May give false positive results for urine glucose. In this case, it is recommended to use

the glucose oxidant method for determining the concentration of glucose in urine.

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

Side effects:

From the digestive system: nausea, vomiting, diarrhea, gastritis, stomatitis, glossitis, increased activity of hepatic transaminases, in isolated cases – cholestatic jaundice, hepatitis, liver failure (more often in the elderly, men, with prolonged therapy), pseudomembranous and hemorrhagic colitis ( can also develop after therapy), enterocolitis, black “hairy” tongue, darkening of tooth enamel.

From the side of hematopoietic organs: a reversible increase in prothrombin time and bleeding time, thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolytic anemia.

From the nervous system: dizziness, heada hyperactivity, anxiety, change in behavior, seizures.

Local reactions: in some cases – phlebitis at the intravenous injection site.

Allergic reactions: urticaria, erythematous rash, rarely – exudative erythema multiforme, anaphylactic shock, angioedema, extremely rarely – exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome), serous allergic vasculitis, pustular syndrome, similar to acute exothermic …

Others: candidiasis, development of superinfection, interstitial nephritis, crystalluria, hematuria.

Storage method:

At a temperature not higher than 30 degrees.

Packaging:

The cardboard box holds a blister of 10 tablets, paper instructions.