Tiratam 500 mg 20 tablets

Tradename:

Tiratam

Compound:

Each tablet contains:

Levetiracetam 500 mg

Auxiliary components:

Lactose monohydrate, croscarmellose sodium, magnesium stearate, hydroxypropyl cellulose, titanium dioxide, propylene glycol 6000, talc.

Properties:

An antiepileptic drug, a pyrrolidone derivative (S-enantiomer of α-ethyl-2-oxo-1-pyrrolidine-acetamide). The chemical structure differs from known antiepileptic drugs.

One of the mechanisms is based on proven binding to the SV2A synaptic vesicle glycoprotein found in the gray matter of the brain and spinal cord. It is believed that in this way the anticonvulsant effect is realized, which is expressed in counteracting the hypersynchronization of neuronal activity. Does not change normal neurotransmission, but suppresses epileptiform neuronal bursts induced by the GABA agonist bicuculin and excitation of glutamate receptors. The activity of levetiracetam has been confirmed in relation to both focal and generalized epileptic seizures (epileptiform manifestations / photoparoxysmal reaction).

Indications:

As monotherapy for the treatment of partial seizures with or without secondary generalization in patients over 16 years of age with a newly diagnosed epilepsy.

As part of additional therapy in the treatment of: partial convulsions with or without secondary generalization in patients older than 1 month (in the appropriate dosage form for this age) with epilepsy; myoclonic convulsions in patients from 12 years of age with juvenile myoclonic epilepsy; Primarily generalized tonic-clonic seizures in patients from 12 years of age with idiopathic generalized epilepsy.

Dosage and administration:

The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

For oral administration.

Depending on the indications and age of the patient, a single dose is 250-750 mg. Multiplicity of application – 2 times / day.

In children, levetiracetam should be used in the appropriate dosage form, depending on age.

Contraindications:

Hypersensitivity to levetiracetam or other pyrrolidone derivatives, children under 1 month of age.

Carefully:

Elderly patients (over 65 years old); liver disease in the stage of decompensation; kidney failure.

Precautionary measures:

Concomitant antiepileptic drugs (during the period of transfer of patients to levetiracetam) should preferably be discontinued gradually.

Patients with kidney disease and decompensated liver disease are recommended to study kidney function before starting treatment. In connection with the reports of cases of suicide, suicidal intentions and suicide attempts during treatment with levetiracetam, patients should be warned about the need to immediately inform their doctor about the appearance of any symptoms of depression or suicidal intentions.

Influence on the ability to drive vehicles and mechanisms:

Due to the different individual sensitivity to levetiracetam from the side of the central nervous system during the period of treatment, patients should refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Side effects:

From the hemopoietic system: infrequently – thrombocytopenia, leukopenia; rarely – neutropenia, pancytopenia.

From the side of metabolism: often – anorexia; infrequently – increase / decrease in body weight.

From the side of the central nervous system: very often – drowsiness, headache; often – mood swings, emotional lability, depression, aggressiveness, insomnia, nervousness.

From the senses: often – dizziness.

From the respiratory system: often – cough.

From the digestive system: often – nausea, vomiting, diarrhea, abdominal pain, dyspepsia.

On the part of the skin and subcutaneous tissues: often – skin rash.

In children, the most common: vomiting, agitation, mood swings, aggression, emotional lability, conduct disorder, lethargy.

Storage method:

Store at a temperature not exceeding 25 degrees.

Package:

Paragraph
The cardboard box contains 2 blisters of 10 tablets, paper instructions.