Ofusidic Eye drops 5 ml

Ofusidic Eye drops 5 ml

Composition:

• Fusidic acid — 1%.

Ofusidic 1% is an antibacterial ophthalmic preparation.
Ofusidic is a sterile eye gel based on fusidic acid, used to treat bacterial eye infections such as conjunctivitis and blepharitis.

Pharmacological properties:

Fusidic acid is an antibiotic, a derivative of fusidin, with a narrow spectrum of action but high activity against gram-positive bacteria, especially Staphylococcus aureus, including methicillin-resistant strains (MRSA).

1. Mechanism of action
   Fusidic acid inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) on the ribosome. This leads to blocking translocation and stopping bacterial growth. Unlike many antibiotics, it does not destroy bacterial cells but suppresses their reproduction, acting as a bacteriostatic agent.

2. Activity against microorganisms

Fusidic acid is mainly effective against gram-positive microorganisms:

• Staphylococcus aureus (including MRSA)
• Staphylococcus epidermidis
• Corynebacterium spp.
• Streptococcus pneumoniae (to a lesser extent).

Fusidic acid is not active against gram-negative bacteria (e.g., Escherichia coli, Pseudomonas aeruginosa), viruses, or fungi.

3. Pharmacokinetics in topical ophthalmic use

• When instilled in the eye, the drug forms a viscous layer on the conjunctival surface, providing prolonged action.
• Systemic absorption with topical use is minimal, reducing the risk of side effects.
• The retention time on the eye surface is significantly longer than standard drops, allowing the medication to be used only twice a day.

4. Resistance

Resistance to fusidic acid rarely develops during short treatment courses. However, prolonged continuous use may lead to resistance, especially with systemic administration.

Indications for use:

• Bacterial conjunctivitis
• Blepharitis
• Superficial eye infections caused by fusidic acid–sensitive microorganisms.

Method of application and dosage:

Adults and children:

• Instill 1 drop of the gel into the conjunctival sac of the affected eye twice daily (morning and evening).
• The usual treatment course lasts 7 days, and may be extended if prescribed by a doctor.