Memexa 10 mg, 30 tabs

Trade Name:

Memexa

Composition:

Each tablet contains:

Memantine hydrochloride 10 mg

Inactive ingredients:

Avicel, lactose monohydrate, aerosil, talc, magnesium stearate, titanium dioxide, ethanol 96%.

Properties:

A remedy for the treatment of dementia. It is a non-competitive antagonist of glutamate NMDA receptors (including in the substantia nigra), as a result, it reduces the excessive stimulating effect of cortical glutamate neurons on the neostriatum, which develops against the background of insufficient release of dopamine. By reducing the flow of Ca2+ into neurons, it reduces the possibility of their destruction.

It has nootropic, cerebral vasodilation, antihypoxic and psychostimulant effects.

Improves impaired memory, increases the ability to concentrate, reduces fatigue and symptoms of depression, reduces spasticity of skeletal muscles caused by diseases or brain damage.

Indications:

Moderate to severe dementia in Alzheimer’s disease.

Dosage and administration:

The optimal dosing regimen is determined by the doctor. Compliance of the used dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

When taken orally, the initial dose for adults is 5 mg / day. In the future, the dose can be increased weekly by 5 mg. The average maintenance dose is 10-20 mg / day. The maximum dose is 20 mg / day.

Contraindications:

Hypersensitivity to memantine; severe liver failure; pregnancy; lactation period (breastfeeding); children and adolescents under 18 years of age (efficacy and safety of the drug have not been established).

With caution: epilepsy, thyrotoxicosis, predisposition to the development of seizures.

Warnings and precautions:

In patients with epilepsy, renal failure, thyrotoxicosis, a history of seizures, arterial hypertension, a history of myocardial infarction, heart failure.

The concomitant use of memantine and NMDA receptor antagonists such as amantadine, ketamine or dextromethorphan should be avoided. These compounds act on the same receptor system as memantine, therefore adverse reactions (mostly CNS related) may occur more frequently and be more severe.

Side effects:

From the immune system: often – hypersensitivity reactions.

On the part of the psyche: often – drowsiness; infrequently – confusion, hallucinations.

From the nervous system: often – dizziness, imbalance; infrequently – gait disturbance; very rarely – convulsions.

From the side of the cardiovascular system: often – increased blood pressure; infrequently – heart failure, venous thrombosis and / or thromboembolism.

From the digestive system: often – constipation; infrequently – vomiting, nausea; frequency unknown – pancreatitis.

From the side of the liver and biliary tract: often – elevated levels of liver enzymes; frequency unknown – hepatitis.From the hematopoietic system: the frequency is unknown – agranulocytosis, leukopenia (including neutropenia), pancytopenia, thrombocytopenia, thrombocytopenic purpura.

Other: often – headache, shortness of breath.

Storage:

Store at a temperature not exceeding 30°C.

Package:

The carton box contains 1 blister of 10 tabs, paper leaflet.