Coversil plus 5/1.25 mg 15 tablets

Tradename:

Coversil Plus

Coversyl Plus

Compound:

Each tablet contains:

Perindopril arginine 10 mg

Indapamide 1.25 mg

Auxiliary components:

Lactose monohydrate, magnesium stearate, maltodextrin, sodium glycodal, glycerol, hypromellose, macrogol, titanium dioxide.

Properties:

The combination of perindopril and indapamide enhances the antihypertensive effect of each of them.

Indapamide:

Indapamide belongs to the group of sulfonamides, in terms of pharmacological properties it is close to thiazide diuretics. Indapamide inhibits the reabsorption of sodium ions in the cortical segment of the loop of Henle, which leads to an increase in the excretion of sodium ions, chloride ions and, to a lesser extent, potassium and magnesium ions, thereby increasing diuresis and reducing blood pressure.

Perindopril:

Perindopril is an inhibitor of the enzyme that converts angiotensin I to angiotensin II (ACE inhibitor). ACE, or kininase II, is an exopeptidase that both converts angiotensin I to the vasoconstrictor angiotensin II and breaks down the vasodilator bradykinin to an inactive heptapeptide. As a result, perindopril reduces the secretion of aldosterone; by the principle of negative feedback increases the activity of renin in the blood plasma; with prolonged use, it reduces OPSS, which is mainly due to the effect on blood vessels in the muscles and kidneys. These effects are not accompanied by sodium and fluid retention or the development of reflex tachycardia.

Perindopril normalizes myocardial function, reducing preload and afterload.

Indications:

-essential hypertension;

– in patients with arterial hypertension and type 2 diabetes mellitus to reduce the risk of developing microvascular complications (from the kidneys) and macrovascular complications from cardiovascular diseases.

Dosage and administration:

Oral intake.

The drug is taken 1 tablet per day, preferably in the morning before meals.

For elderly patients, the drug is prescribed under the condition of normal kidney function, while the degree of reduction in blood pressure should be monitored.

Contraindications:

– hypersensitivity to indapamide and other sulfonamides;

– severe renal dysfunction (CC less than 30 ml / min);

– hepatic encephalopathy;

– severe liver dysfunction;

-hypokalemia;

– joint use with non-antiarrhythmic drugs that can cause polymorphic ventricular tachycardia of the “pirouette” type is impractical;

– period of breastfeeding;

-Children up to 18 years of age.

Perindopril:

– Hypersensitivity to the active substance and other ACE inhibitors;

– angioedema (Quincke’s edema) in history while taking other ACE inhibitors;

-hereditary/idiopathic angioedema;

-pregnancy;

– period of breastfeeding;

– combined use with angiotensin II receptor antagonists (ARA II) in patients with diabetic nephropathy;

– joint use with a combination of valsartan + sacubitril;

– extracorporeal therapy, leading to blood contact with negatively charged surfaces;

– pronounced bilateral stenosis of the renal arteries or stenosis of the artery of the only functioning kidney;

-Children up to 18 years of age.

Precautionary measures:

The use of the drug Coversil plus is not accompanied by a significant decrease in the frequency of side effects, with the exception of hypokalemia, compared with taking the individual components of the drug in the lowest doses allowed for use. At the beginning of therapy with two antihypertensive drugs that the patient has not previously received, an increased risk of idiosyncrasy cannot be ruled out. Careful monitoring of the patient minimizes this risk.

Side effects:

The most common side effects were:

– for perindopril: dizziness, headache, paresthesia, dysgeusia, blurred vision, vertigo, tinnitus, hypotension, cough, shortness of breath, abdominal pain, constipation, dyspepsia, diarrhea, nausea, vomiting, pruritus, skin rash, muscle spasms and asthenia;

– for indapamide: hypersensitivity reactions, mainly skin, in patients predisposed to allergic and asthmatic reactions, and maculo-papular rash.

Storage method:

Store at a temperature not exceeding 30 degrees.

Package:

The cardboard box contains 15 tablets and paper instructions.