Tradename:

Coloverin

Composition:

Each tablet contains:

Mebeverine hydrochloride 135 mg

Properties:

Myotropic antispasmodic, has a direct effect on the smooth muscles of the gastrointestinal tract without affecting the normal intestinal motility. The exact mechanism of action is unknown, but multiple mechanisms, such as decreased ion channel permeability, blockade of norepinephrine reuptake, local anesthetic action, and altered water absorption can cause mebeverine to act locally on the gastrointestinal tract. Through these mechanisms, mebeverine exhibits an antispasmodic effect, normalizing intestinal motility and not causing constant relaxation of smooth muscle cells of the gastrointestinal tract (“hypotension”).

Indications:

Symptomatic treatment of bowel pain, cram s, dysfunction and discomfort associated with irritable bowel syndrome (symptoms may include abdominal pain, cramping, bloating and

flatulence, changes in stool frequency

(diarrhea, constipation or alternating diarrhea and constipation), changes in constipation chair).

Method of administration and dosage:

1 tablet 3 times a day. Take 20 minutes before meals.

Hypersensitivity to mebeverine; age up to 18 years; pregnancy, breastfeeding period.

Precautions:

Before starting the use of mebeverine, the patient should consult a doctor in the following cases: if the symptoms of the disease have arisen for the first time; with unintentional and unexplained weight loss; with anemia; with rectal bleeding or blood in the stool; with fever; if the patient’s family has been diagnosed with colon cancer, celiac disease or inflammatory bowel disease; if the patient is over 50 years old and if the symptoms of the disease occurred for the first time; in case of recent of antibiotics.

Side effects:

Skin and subcutaneous tissue disorders: urticaria (allergic rash), angioedema (serious allergic reaction, which may include: difficulty breathing, swelling of the face, neck, lips, tongue, throat), facial edema, exanthema (skin rash).

From the immune system: hypersensitivity reactions (anaphylactic reactions – serious allergic reactions that may include difficulty breathing, rapid pulse, a sharp decrease in blood pressure (weakness and dizziness), increased sweating).

Storage method:

At a temperature not higher than 30 degrees.

Packaging:

The cardboard box contains 1,2 or 3 blisters of 10 tablets, paper instructions.