Zyrovazet 10 mg/40 mg 30 tablets

Zyrovazet 10 mg/40 mg 30 tablets

Composition:

Each tablet contains:
Rosuvastatin — 40 mg;
Ezetimibe — 10 mg.
Excipients: microcrystalline cellulose, lactose monohydrate, povidone K30, poloxamer 407, sodium lauryl sulfate, sodium croscarmellose, magnesium stearate

Product Description:

Zirovazet is a lipid‑lowering medicine combining rosuvastatin and ezetimibe.
It is used in adults to reduce total cholesterol, LDL cholesterol, and triglycerides, while increasing HDL cholesterol.
It works through a dual mechanism: rosuvastatin inhibits cholesterol synthesis in the liver, and ezetimibe blocks cholesterol absorption in the intestine.

Indications for Use:

• As adjunct to diet for reduction of elevated total cholesterol and LDL cholesterol.
• As adjunct to diet for patients with elevated triglycerides.
• In patients with cardiovascular disease, to reduce LDL cholesterol to < 100 mg/dL.
• Homozygous familial hypercholesterolemia.

Method of Administration and Dosage:

• Take as directed by a physician.
• Recommended dose: 1 tablet daily, with or without food.
• Dose is individualized depending on treatment goals and patient response.
• No dose adjustment required in renal impairment.
• Not recommended in patients with hepatic dysfunction.

Contraindications:

Hypersensitivity to rosuvastatin or ezetimibe.
Severe liver disease.
Pregnancy and breastfeeding.

Precautions:

• Use with caution when co‑administered with erythromycin (may increase plasma rosuvastatin levels).
• Caution in patients with liver disease or alcohol abuse.
• Discontinue temporarily if polymyositis symptoms or rhabdomyolysis occur.
• Use cautiously with drugs affecting steroid hormone levels (ketoconazole, spironolactone, cimetidine).
• Do not use in patients with hereditary lactose intolerance.
• Women of childbearing potential should use only when pregnancy is excluded and risks are understood.

Adverse Effects:

• Upper respiratory tract infections.
• Headache, stress.
• Muscle and back pain.
• Sinusitis.
• Diarrhea, abdominal pain.

Pregnancy and Lactation:

Contraindicated.
Not to be used during pregnancy or breastfeeding.

Storage Conditions:

Store at temperatures not exceeding 30 °C, in a dry place, out of reach of children.

Packaging:

Cardboard box containing 3 blisters of 10 film‑coated tablets, with patient information leaflet.