Ursoplus 20 capsules

Tradename:

Ursoplus

Ursoplus

Composition:

Each capsule contains:

ursodeoxycholic acid 250 mg

silymarin 140 mg

Properties:

Hepatoprotector. Ursodeoxycholic acid is a bile acid. Reduces cholesterol in bile mainly by dispersing cholesterol and forming a liquid crystal phase. It has an effect on the enterohepatic circulation of bile salts, reducing the reabsorption of endogenous, more hydrophobic and potentially toxic compounds in the intestine.

In vitro studies have shown that ursodeoxycholic acid has a direct hepatoprotective effect and reduces the hepatotoxicity of hydrophobic bile salts.

It has an effect on immunological reactions, reducing the pathological expression of class I HLA antigens on hepatocytes and suppressing the production of cytokines and interleukins.

Ursodeoxycholic acid reduces the lithogenic index of bile, increasing the content of bile acids in it. Promotes the partial or complete dissolution of cholesterol gallstones when taken orally. It has a choleretic effect.

Silymarin:

It belongs to the group of hepatoprotectors. It prevents the destruction of cell membranes, which is due to the ability to inhibit lipid peroxidation. Stimulates the synthesis of protein and phospholipids in damaged hepatocytes, as a result of this, cell membranes are stabilized, and the loss of cell components is prevented. It prevents the penetration of some hepatotoxic substances into the cell (in particular, the toadstool’s poisons).

Silibinin is the main component of silymarin, a biologically active substance of the fruits of milk thistle.

Indications:

Cholesterol gallstones in the gallbladder and common bile duct in patients when surgical or endoscopic treatment is not possible. Cholesterol stones of the gallbladder and common bile duct with a diameter of not more than 1.5-2 cm after extracorporeal lithotripsy or mechanical lithotripsy. Primary biliary cirrhosis (before the formation of advanced fibrosis and cirrhosis of the liver). Chronic active hepatitis with cholestatic syndrome. Acute hepatitis, cystic fibrosis of the liver, congenital atresia of the bile duct. Biliary reflux esophagitis and gastritis. Biliary dyspeptic syndrome in cholecystopathy and biliary dyskinesia. Prevention and treatment of cholestatic syndrome caused by the use of hormonal contraceptives. To normalize liver function in patients receiving therapy with cytostatics, as well as in patients with alcoholic liver damage. Liver and other organ transplantation (adjunctive treatment).

Method of administration and dosage:

The optimal dosage regimen is determined b the doctor. The compliance of the used dos form of a particular drug with indications for use and dosage regimen should be strictly

observed.

Set individually. Usually used at a dose of up to 10 mg / kg / day. The daily dose is taken once in the evening. The duration of treatment depends on the indications.

Contraindications:

Hypersensitivity to silymarin.

Acute inflammatory diseases of the gallbladder and biliary tract, cirrhosis of the liver in the stage of vascular and parenchymal decompensation and / or severe activity, NUC, Crohn’s disease, severe renal dysfunction, hypersensitivity to ursodeoxycholic acid.

Precautions:

For successful litholysis with ursodeoxycholic acid, the following conditions must be met: the stones must be purely cholesterol, i.e. do not give a shadow on the x-ray; the size of the stones should not exceed 15-20 mm; the gallbladder must fully maintain its function; the gallbladder should be filled with stones no more than half; the patency of the cystic du must be preserved; the common bile duct must be free of stones.

When using ursodeoxycholic acid to dissolve gallstones in the first 3 months of treatment, it is necessary to determine the activity of liver transaminases every 4 weeks. In the future, these studies can be carried out at intervals of 3 months.

To monitor the effectiveness of treatment, it is recommended to conduct an X-ray and ultrasound examination of the biliary tract every 6 months.

To prevent recurrence of cholelithiasis, treatment must be continued for several months after the dissolution of gallstones.

Side effects:

Possibly: a transient increase in the activity of hepatic transaminases, skin itching, allergic reactions.

Rarely: diarrhea, calcification of gallstones.

Rarely: laxative effect, allergic reactions.

Storage method:

At a temperature not higher than 30 degrees.

Packaging:

The cardboard box contains 2 blisters of 10 capsules.