Cemicresto 10 mg 28 tablets

Cemicresto

Compound:

Each tablet contains Rosuvastatin calcium 10.40 mg (equivalent to rosuvastatin 10 mg)

Auxiliary components:

Microcrystalline cellulose, lactose monohydrate, povidone K25, magnesium stearate.

Properties:

Rosuvastatin is a synthetic lipid-lowering agent from the statin group, an inhibitor of GMC-CoA reductase. Inhibition of the activity of HMG-CoA reductase leads to a series of successive reactions, resulting in a decrease in the intracellular cholesterol content and a compensatory increase in the activity of LDL receptors and, accordingly, an acceleration of LDL cholesterol (Xc) catabolism.

Indications:

Treatment of hypercholesterolemia in adults with primary hypercholesterolemia (type IIa, including heterozygous familial hypercholesterolemia) or mixed hypercholesterolemia (type IIb) as an adjunct to diet when diet and other non-drug treatments (exercise, weight loss) are inadequate. Homozygous familial hypercholesterolemia as an adjunct to diet and other cholesterol-lowering therapy, or when such therapy is not appropriate for the patient. To slow the progression of atherosclerosis as an adjunct to diet in patients who are indicated for therapy to reduce the concentration of total cholesterol and LDL-C. Primary prevention of major cardiovascular complications (stroke, heart attack) in adult patients without clinical signs of coronary artery disease, but with an increased risk of its development.

Dosage and administration:

Inside, swallow the tablet whole with water. The drug can be administered at any time of the day, regardless of food intake. Before starting therapy, the patient should begin to follow a standard hypocholesterolemic diet and continue to follow it during treatment. The dose of the drug should be selected individually depending on the goals of therapy. The recommended starting dose for patients should be 5 mg 1 time / day. If necessary, the dose may be increased after 4 weeks. Careful monitoring of patients receiving the drug at a dose of 40 mg is recommended.

Contraindications:

Hypersensitivity to rosuvastatin or any of the components of the drug;

– lactose intolerance, lactase deficiency or glucose-galactose malabsorption;

– children’s age up to 18 years;

– liver disease in the active phase;

– severe violations of kidney function;

– myopathy;

– simultaneous reception of cyclosporine;

-pregnancy and lactation.

Precautionary measures:

Use with caution in renal failure, hypothyroidism, personal or family history of hereditary muscle diseases and a previous history of muscle toxicity when using other HMG-CoA reductase inhibitors, in chronic alcoholism, in patients over the age of 65 years, with a history of liver disease, sepsis , arterial hypotension, during major surgical interventions, trauma, severe metabolic endocrine or electrolyte disorders, with uncontrolled epilepsy, in people of Asian origin (Chinese, Japanese). When using rosuvastatin at a dose of 40 mg, it is recommended to monitor indicators of kidney function.

Side effects:

The drug is usually well tolerated. Adverse events observed when taking it are usually mild and transient. Headache, myalgia, asthenia, constipation, dizziness, nausea, abdominal pain, diabetes mellitus; itching, rash and hives; myopathy, hypersensitivity reactions, pancreatitis; jaundice, hepatitis; arthralgia; memory loss.

Storage:

Store at a temperature not exceeding 30C in a place protected from moisture and out of the reach of children.

Package:

Cardboard pack contains 2 blisters of 14 tablets, paper instructions.