Motil Fast 10 mg 10 sachets

Tradename:

Motil Fast

Compound:

Each sachet contains:

Domperidone 0.01 g

Auxiliary components:

Sodium bicarbonate, citrus acid, sodium saccharin, povidone, lemon flavor, alcohol 96%.

Properties:

Domperidone is a dopamine antagonist with antiemetic properties. Domperidone does not penetrate well through the BBB. The use of domperidone is rarely accompanied by extrapyramidal side effects, especially in adults, but domperidone stimulates the release of prolactin from the pituitary gland. Its antiemetic effect may be due to a combination of peripheral (gastrokinetic) action and antagonism to dopamine receptors in the chemoreceptor trigger zone, which is outside the BBB.

When administered orally, domperidone increases the duration of antral and duodenal contractions, accelerates gastric emptying, and increases lower esophageal sphincter pressure. Domperidone has no effect on gastric secretion.

Indications:

– to relieve symptoms of nausea and vomiting.

Dosage and administration:

The drug is taken orally. It is recommended to take Motil Fast sachets 15-30 minutes before a meal, if the drug is taken after a meal, the absorption of domperidone may slow down.

Adults and adolescents over 12 years of age and children weighing ≥35 kg – 1 sachet. (10 mg) 3 times / day, the maximum daily dose is 3 sachets. (30 mg).

Children under 12 years of age and weighing 35 kg or more – 1 sachet. (10 mg) 3 times / day, the maximum daily dose is 3 sachets. (30 mg).

Contraindications:

– hypersensitivity to domperidone or any other component of the drug;

-prolactinoma;

– simultaneous use of oral forms of ketoconazole, erythromycin or other potent inhibitors of the CYP3A4 isoenzyme, causing a prolongation of the QT interval, with the exception of apomorphine;

severe electrolyte disturbances or heart disease, such as chronic heart failure;

– bleeding from the gastrointestinal tract, mechanical intestinal obstruction, perforation of the stomach or intestines;

– hepatic insufficiency of moderate and severe severity;

– body weight less than 35 kg;

-children under 12 years of age with a body weight of less than 35 kg;

-pregnancy;

– period of breastfeeding.

With caution: children’s age, impaired renal function.

Precautionary measures:

Domperidone is not recommended for the prevention of nausea and vomiting after anesthesia.

With prolonged therapy with the drug, patients should be under regular medical supervision.

Domperidone can cause prolongation of the QT interval on the ECG. During post-marketing studies in patients taking domperidone, in rare cases, there was an increase in the QT interval and the occurrence of ventricular tachycardia of the “pirouette” type. These adverse reactions were observed mainly in patients with risk factors, with severe electrolyte disturbances or concomitantly taking drugs that increase the QT interval.

Side effects:

Mental disorders: infrequently – irritability, nervousness.

From the nervous system: often – dizziness; rarely – convulsions; frequency unknown – extrapyramidal disorders.

From the side of the cardiovascular system: the frequency is unknown – ventricular arrhythmia *, ventricular tachycardia of the “pirouette” type, sudden coronary death *.

From the gastrointestinal tract: the frequency is unknown – dry mouth.

From the skin and subcutaneous tissues: the frequency is unknown – angioedema.

From the side of the kidneys and urinary tract: infrequently – urinary retention.

Laboratory and instrumental data: infrequently – deviations in laboratory parameters of liver function; rarely – hyperprolactinemia.

Storage method:

Store at a temperature not exceeding 25 degrees.

In a dry place.

Package:

The cardboard box contains 10 sachets of 5 grams.