Midodrine 1% oral drops 10 ml

Tradename:

Midodrin

Midodrine

Composition:

Each 1 ml of solution contains:

Midodrina hydrochloride 10 mg

Auxiliary components:

Propylene glycol, sucrose, purified water.

Properties:

Alpha-adrenergic agonist. Selectively stimulates peripheral α-adrenergic receptors of the sympathetic nervous system. It causes an increase in vascular tone, which, in turn, increases the systemic vascular resistance, increases blood pressure and prevents (with orthostatic disorders) blood stagnation in the venous circle. As a result, the BCC and blood pressure remain at a constant level, the blood supply to the organs increases, and thereby orthostatic reactions are eliminated (including morning weakness and fatigue, frequent yawning, dizziness).

Does not affect the activity of the heart, however, a reflex decrease in heart rate is possible. Does not increase the excitability of the central nervous system.

Stimulating α-adrenergic receptors located in the sphincter of the bladder, the urethra, midodrin increases their tone and has a therapeutic effect in involuntary urination.

Indications:

Orthostatic dysregulation of vascular tone, constitutional hypotension, symptomatic hypotension (including during convalescence, after surgery, childbirth); hypotensive lability when the weather changes, morning weakness and a feeling of fatigue; spontaneous urination with a disorder of the function of the sphincter of the bladder.

Method of administration and dosage:

Take 7 drops orally 2-3 times a day. The maximum daily dosage is 28 drops.

The last dose of the drug is at least 4 hours before bedtime.

Contraindications:

Hypersensitivity to midodrin; arterial hypertension, pheochromocytoma, obliterating arterial disease, acute nephritis, severe renal failure, angle-closure glaucoma, benign prostatic hyperplasia with residual urine, mechanical obstruction of the urinary tract, hyperthyroidism.

Precautionary measures:

It should be used with caution in patients with chronic heart failure, renal and / or hepatic failure, heart rhythm disturbances.

When carrying out long-term therapy, it is necessary to monitor renal function.

With simultaneous use with other drugs that have a direct or indirect effect on blood pressure or heart rate (including with guanethidine, beta-blockers), careful monitoring of blood pressure and heart rate is required.

Particular attention in the selection of doses is necessary for patients with arterial hypertension and hypotensive lability when the weather changes.

Prohibited for use in athletes (refers to doping drugs).

Side effects:

From the side of the cardiovascular system: increased blood pressure (including lying down), facial flushing, bradycardia.

From the urinary system: urination disorder (increased frequency or delay).

From the nervous system: headache, dizziness, insomnia, drowsiness, asthenia, paresthesia.

From the digestive system: heartburn, dry mouth, nausea, dyspepsia, flatulence.

Dermatological reactions: sweating, pilomotor reaction (goose bumps), pruritus, chills.

Storage method:

Store at a temperature not exceeding 25 degrees.

Package:

The cardboard box holds a 10 ml dropper bottle, paper instructions.