Megamox 457mg/5ml suspension 70ml

Megamox

Compound:

Each 5 ml suspension contains:

Amoxicillin 400 mg

Clavulanic acid 57 mg

Properties:

Combined preparation of amoxicillin and clavulanic acid, a beta-lactamase inhibitor. It acts bactericidal, inhibits the synthesis of the bacterial wall.

Active against aerobic Gram-positive bacteria (including beta-lactamase producing strains): Staphylococcus aureus; aerobic gram-negative bacteria: Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., Moraxella catarrhalis. The following pathogens are sensitive only in vitro: Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus anthracis, Streptococcus pneumoniae, Streptococcus viridans, Enterococcus faecalis, Corynebacterium spp., Listeria monocytogenes; anaerobic Clostridium spp., Peptococcus spp., Peptostreptococcus spp.; as well as aerobic gram-negative bacteria (including beta-lactamase producing strains): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp., Bordetella pertussis, Yersinia enterocolitica, Gardnerella vaginalis, Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus ducreyi, Yersinia multocida ( formerly Pasteurella), Campylobacter jejuni; anaerobic gram-negative bacteria (including beta-lactamase producing strains): Bacteroides spp., including Bacteroides fragilis. Clavulanic acid inhibits types II, III, IV and V of beta-lactamases, is not active against type I beta-lactamases produced by Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high affinity for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases.

Indications:

Treatment of infectious and inflammatory diseases caused by susceptible pathogens: infections of the lower respiratory tract (bronchitis, pneumonia, pleural empyema, lung abscess); infections of ENT organs (sinusitis, tonsillitis, otitis media); infections of the genitourinary system and pelvic organs (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingo-oophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, septic abortion, postpartum sepsis, pelvic peritonitis, soft chancre, gonorrhea); infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, abscess, phlegmon, wound infection); osteomyelitis; postoperative infections.

Dosage and administration:

Children under 12 years old: 20-40 mg / kg / day in 2-3 doses.

Adults and children over 12 years of age or weighing 40 kg or more: 250-500 mg 2-3 times / day or 875 mg 2 times / day.

Contraindications:

Hypersensitivity to amoxicillin and other penicillins, clavulanic acid, other beta-lactam antibiotics (cephalosporins, carbapenems, monobactams); cholestatic jaundice and / or other abnormal liver function caused by the use of amoxicillin / clavulanic acid in history; severe renal dysfunction (CC <30 ml / min) (for a dosage form intended for use in children from 3 months to 12 years).

Precautionary measures:

This combination is not recommended for suspected infectious mononucleosis.

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken with food.

Perhaps the development of superinfection due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.

May give false positive results in the determination of glucose in the urine. In this case, it is recommended to use a glucose oxidant method for determining the concentration of glucose in the urine.

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

Side effects:

From the digestive system: nausea, vomiting, diarrhea, gastritis, stomatitis, glossitis, increased activity of hepatic transaminases, in isolated cases – cholestatic jaundice, hepatitis.

On the part of the hematopoietic organs: a reversible increase in prothrombin time and bleeding time, thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolytic anemia.

From the nervous system: dizziness, headache, hyperactivity, anxiety, behavioral changes, convulsions.

From the urinary system: interstitial nephritis, crystalluria, hematuria.

Allergic reactions: urticaria, erythematous rash.

Others: candidiasis, development of superinfection.

Storage method:

Store at a temperature not exceeding 30 degrees.

Package:

The cardboard box contains a bottle of powder for oral suspension, paper instructions.

To prepare the suspension, add 62 ml of water.