Capotril 50 mg 20 tablets

Capotril 50 mg 20 tablets

Composition:

Each tablet contains:
Captopril 50 mg

Auxiliary components: 

Microcrystalline cellulose, talc, magnesium stearate, lactose, sodium glycolate.

Properties:

The mechanism of antihypertensive action is associated with competitive inhibition of ACE activity, which leads to a decrease in the rate of conversion of angiotensin I to angiotensin II and eliminates its vasoconstrictor effect. As a result of a decrease in the concentration of angiotensin II, a secondary increase in plasma renin activity occurs due to the elimination of negative feedback during the release of renin and a direct decrease in aldosterone secretion. Due to its vasodilating action, it reduces the total peripheral vascular resistance (afterload), the pressure of wedging in the pulmonary capillaries (preload) and the resistance in the pulmonary vessels; increases cardiac output and exercise tolerance. Does not affect lipid metabolism.  

Indications:

-arterial hypertension (including renovascular); – chronic heart failure (as part of combination therapy).  

Method of administration and dosage:

Capotril is prescribed one hour before meals. The dosage regimen is set individually. In case of arterial hypertension, the drug is prescribed at an initial dose of 25 mg 2 times / day. If necessary, the dose is gradually increased (with an interval of 2-4 weeks) until the optimal effect is achieved. For mild or moderate arterial hypertension, the usual maintenance dose is 25 mg 2 times / day; the maximum dose is 50 mg 2 times / day. In severe arterial hypertension, the maximum dose is 50 mg 3 times / day. The maximum daily dose is 150 mg. For the treatment of chronic heart failure, Capotril is prescribed in cases where the use of diuretics does not provide an adequate effect. The initial dose is 6.25 mg 2-3 times / day, which is then gradually increased (with an interval of at least 2 weeks). The average maintenance dose is 25 mg 2-3 times / day. In the future, if necessary, the dose is gradually increased (with an interval of at least 2 weeks). The maximum dose is 150 mg / day.  

Contraindications:

– angioedema, incl. hereditary, history (including history after using other ACE inhibitors); – severe renal dysfunction, azotemia, hyperkalemia, bilateral renal artery stenosis or stenosis of a single kidney with progressive azotemia, condition after kidney transplantation, primary hyperaldosteronism; – stenosis of the aortic orifice, mitral stenosis, the presence of other obstacles to the outflow of blood from the left ventricle of the heart; – severe liver dysfunction; -arterial hypotension; -cardiogenic shock; -pregnancy and lactation period; – age up to 18 years (efficacy and safety have not been established). -increased sensitivity to captopril and other ACE inhibitors.  

Precautionary measures:

Before starting, as well as regularly during treatment with Capotril, kidney function should be monitored. In chronic heart failure, the drug is used subject to careful medical supervision. With extreme caution, Capotril is prescribed to patients with diffuse connective tissue diseases or systemic vasculitis; patients receiving immunosuppressive drugs, especially in the presence of impaired renal function (risk of developing serious infections that do not respond to antibiotic therapy). In such cases, the peripheral blood picture should be monitored before using Capotril, every 2 weeks during the first 3 months of therapy and periodically in the subsequent period of treatment.  

Side effects:

From the side of the cardiovascular system: a marked decrease in blood pressure, tachycardia, orthostatic hypotension, peripheral edema. From the urinary system: proteinuria, impaired renal function (increased levels of urea and creatinine in the blood). From the side of the central nervous system: dizziness, headache, ataxia, paresthesia, drowsiness, blurred vision, fatigue, asthenia. From the respiratory system: dry cough that passes after discontinuation of the drug, bronchospasm, pulmonary edema.  

Storage method:

Store at a temperature not exceeding 30 degrees.  

Package:

The cardboard box contains 2 blisters of 10 tablets, paper instructions.