Inegy 10 mg/20 mg 14 tablets

Tradename:

Inegy

Compound:

Each tablet contains:

ezetimibe 10 mg

simvastatin 20 mg

Auxiliary components:

lactose monohydrate, microcrystalline cellulose, hypromellose, croscarmellose sodium, citric acid monohydrate, butylhydroxyanisole, propyl gallate, magnesium stearate.

Properties:

Combined lipid-lowering agent that reduces the absorption of cholesterol and related plant sterols in the intestine, and also suppresses endogenous cholesterol synthesis.

Simvastatin reduces both elevated and normal LDL levels. LDL is formed from VLDL and is cleaved predominantly by the high-affinity LDL receptor. The decrease in LDL after taking simvastatin leads to a decrease in the content of VLDL and activation of LDL receptors, which leads to a decrease in the formation and increased catabolism of LDL. With simvastatin therapy, ApoB levels also decrease. In addition, simvastatin modestly increases HDL levels and reduces plasma TG. As a result of these changes, total cholesterol and LDL levels decrease.

ezetimibe

The mechanism of action of ezetimibe differs from other classes of lipid-lowering agents (eg, statins, bile acid sequestrants, fibrates).

Ezetimibe, when entering the small intestine, slows down the absorption of cholesterol, which leads to a decrease in the flow of cholesterol from the intestine to the liver.

After 2 weeks of use, ezetimibe reduced intestinal cholesterol absorption by 54% compared with placebo.

Indications:

Primary hypercholesterolemia: heterozygous (familial and non-familial) hypercholesterolemia or mixed hyperlipidemia (as an adjunct to a diet to reduce total cholesterol, LDL, apolipoprotein B, triglycerides, low density lipoproteins, to increase HDL levels);

homozygous familial hypercholesterolemia: to reduce elevated levels of total cholesterol and LDL (both as an adjunct to other lipid-lowering therapy, such as LDL apheresis, and in its absence).

Dosage and administration:

Inside 1 time / day. The dosage regimen is individual, depending on the indications, the age of the patient and the clinical situation.

Contraindications:

Liver disease in the active phase or a persistent increase in the activity of hepatic transaminases of unclear etiology;

– moderate and severe liver failure (7 or more points on the Child-Pugh scale);

-pregnancy;

– lactation period (breastfeeding);

– age up to 18 years;

– concomitant treatment with strong inhibitors of the CYP3A4 isoenzyme (itraconazole, ketoconazole, voriconazole, HIV protease inhibitors and drugs containing cobicistat);

– concomitant treatment with gemfibrozil, cyclosporine or danazol.

Precautionary measures:

If necessary, the appointment of patients with severe renal insufficiency (CC < 30 ml / min) at a dose of more than 10/10 mg / day should be used with caution.

Use with caution in patients who drink large amounts of alcohol and/or have a history of liver disease. Acute liver disease or inexplicably persistent high levels of liver enzymes are contraindications to taking this combination.

A few days before major surgery and in the early postoperative period, it is recommended to temporarily stop taking it.

Simvastatin, like other inhibitors of HMG-CoA reductase, can cause myopathy, manifested by muscle pain, weakness, fatigue, and an increase in CPK levels more than 10 times relative to ULN.

Side effects:

From the digestive system: flatulence, abdominal pain, constipation, diarrhea, dyspepsia, vomiting, cholelithiasis, cholecystitis, jaundice, hepatitis; nausea; pancreatitis; in some cases – liver failure.

From the hemopoietic system: thrombocytopenia, anemia.

From the musculoskeletal system: arthralgia, muscle weakness, muscle spasms, neck pain, pain in the extremities.

From the nervous system: dizziness, headache.

Allergic reactions: skin rash and urticaria.

Laboratory data: an increase in the activity of “liver” transaminases (ALT and / or AST), an increase in the activity of CPK, an increase in the concentration of bilirubin in the blood, an increase in the activity of gamma-glutamyl transferase, an increase in INR, proteinuria.

Other: fatigue, asthenia, malaise, peripheral edema.

Storage method:

Store at a temperature not exceeding 30 degrees.

Package:

Cardboard box contains 2 blisters of 7 tablets, paper instructions.