Inderal 40 mg 50 tablets

Tradename:

Inderal

Inderal

Compound:

Each tablet contains:

Propranolol hydrochloride 40 mg

Properties:

Non-selective beta-blocker. It has antihypertensive, antianginal and antiarrhythmic effects. Due to the blockade of β-adrenergic receptors, it reduces the formation of cAMP from ATP stimulated by catecholamines, as a result, it reduces the intracellular intake of calcium ions, has a negative chrono-, dromo-, batmo- and inotropic effect (reduces heart rate, inhibits conductivity and excitability, reduces myocardial contractility). At the beginning of the use of beta-blockers, OPSS increases in the first 24 hours (as a result of a reciprocal increase in the activity of α-adrenergic receptors and the elimination of stimulation of β2-adrenergic receptors of skeletal muscle vessels), but after 1-3 days it returns to the original, and decreases with prolonged use.

Indications:

Arterial hypertension, angina pectoris, sinus tachycardia (including with hyperthyroidism), supraventricular tachycardia, tachysystolic form of atrial fibrillation, supraventricular and ventricular premature beats, hypertrophic cardiomyopathy, myocardial infarction, mitral valve prolapse, subaortic stenosis, sympathetic-adrenal crisis in patients with diencephalic syndrome, neurocirculatory dystonia, portal hypertension, essential tremor, panic attacks, aggressive behavior, migraine (prevention), auxiliary treatment for pheochromocytoma (only in combination with alpha-blockers), thyrotoxicosis (including preoperative preparation), thyrotoxic crisis, primary weakness labor activity, menopausal vasomotor symptoms, withdrawal symptoms; treatment of akathisia caused by antipsychotics.

Mode of application:

For adults, when taken orally, the initial dose is 20 mg, a single dose is 40-80 mg, the frequency of administration is 2-3 times / day.

Contraindications:

AV block II and III degree, sinoatrial block, severe bradycardia (less than 50 bpm), arterial hypotension, acute or chronic heart failure in the stage of decompensation, acute myocardial infarction (systolic blood pressure less than 100 mm Hg), cardiogenic shock, pulmonary edema, SSS, Prinzmetal’s angina, cardiomegaly (without signs of heart failure), severe peripheral vascular disorders, metabolic acidosis (including diabetic acidosis), pheochromocytoma (without the simultaneous use of alpha-blockers), bronchial asthma, chronic obstructive lung disease, a tendency to bronchospastic reactions, simultaneous use with antipsychotics and anxiolytics (chlorpromazine, trioxazine and others), MAO inhibitors.

Precautionary measures:

Use with caution in patients with bronchial asthma, COPD, bronchitis, decompensated heart failure, diabetes mellitus, renal and / or hepatic insufficiency, hyperthyroidism, depression, myasthenia gravis, psoriasis, peripheral vascular occlusive diseases, pregnancy, lactation, elderly patients, in children (efficacy and safety have not been determined).

With caution in newborns and infants: cardiovascular disease, heart failure; diabetes; respiratory diseases; psoriasis; RNACE syndrome; hyperkalemia; allergic reactions in history.

During treatment, exacerbation of psoriasis is possible.

With pheochromocytoma, propranolol can be used only after taking an alpha-blocker.

After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician.

Side effects:

From the nervous system: fatigue, weakness, dizziness, headache.

From the sensory organs: a decrease in the secretion of lacrimal fluid (dryness and soreness of the eyes).

From the side of the cardiovascular system: sinus bradycardia, AV blockade.

From the digestive system: nausea, vomiting, discomfort in the epigastric region, constipation or diarrhea.

From the respiratory system: nasal congestion, bronchospasm.

From the endocrine system: a change in the concentration of blood glucose (hypo- or hyperglycemia).

From the hematopoietic system: thrombocytopenia (unusual bleeding and hemorrhage), leukopenia.

Dermatological reactions: increased sweating, psoriasis-like skin reactions, exacerbation of psoriasis symptoms.

Allergic reactions: itching, skin rash, urticaria.

Storage:

Store at a temperature not exceeding 30 degrees.

Package:

The cardboard box contains 5 blisters of 10 tablets, paper instructions.