Heli Cure 14 tablets

Heli Cure 14 tablets

Composition:

Each tablet contains:
Omeprazole — 20 mg.
Clarithromycin — 250 mg.
Tinidazole — 500 mg.
Excipients: mannitol, povidone, sodium croscarmellose, sodium lauryl sulfate, talc, magnesium stearate.

Product Description:

• Combined preparation for eradication therapy of Helicobacter pylori.
• Omeprazole — proton pump inhibitor, reduces gastric acid secretion by blocking H+/K+‑ATPase enzyme.
• Clarithromycin — macrolide antibiotic, inhibits protein synthesis in microbial cells, active against Helicobacter pylori.
• Tinidazole — antimicrobial agent, damages bacterial DNA, effective against anaerobes, protozoa, and Helicobacter pylori.

Indications for Use:

Eradication therapy of Helicobacter pylori in gastric and duodenal ulcer disease.

Method of Administration and Dosage:

Optimal dosing regimen determined by physician.
Typically taken twice daily (morning and evening) with meals.
Average treatment course: 2 weeks.

Contraindications:

• Hypersensitivity to omeprazole, clarithromycin, tinidazole, or macrolides.
• Concomitant use with cisapride, pimozide, astemizole, terfenadine, ethanol.
• Pregnancy and breastfeeding.
• Organic CNS diseases, porphyria.
• Bone marrow suppression.
• Pediatric use.
• Renal and/or hepatic insufficiency.

Precautions:

• Exclude malignancy before therapy, as treatment may mask symptoms.
• Use cautiously with drugs metabolized by the liver.
• Monitor prothrombin time if combined with warfarin or other anticoagulants.
• Avoid combination with terfenadine, cisapride, astemizole in patients with cardiac disease.
• Tinidazole may cause dark urine.
• Exercise caution when driving or operating machinery during therapy.

Adverse Reactions / Side Effects:

• Gastrointestinal: dysbiosis, diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disturbance, metallic taste, reduced appetite, stomatitis, elevated liver enzymes, hepatic dysfunction, hepatitis, rarely pseudomembranous colitis.
• CNS: headache, dizziness, agitation, fatigue, drowsiness, insomnia, paresthesia, depression, hallucinations, seizures, psychosis, tinnitus.
• Musculoskeletal: muscle weakness, myalgia, arthralgia.
• Hematologic: leukopenia, neutropenia, thrombocytopenia, anemia.
• Skin: itching, rash, photosensitivity, erythema multiforme, alopecia.
• Allergic: urticaria, angioedema, bronchospasm, anaphylactic shock.
• Other: tachycardia, interstitial nephritis, vision disturbances, peripheral edema, sweating, fever, gynecomastia.

Pregnancy and Lactation:

Contraindicated.

Storage Conditions:

Store at temperatures not exceeding 30 °C.

Packaging:

Carton box containing 7 blisters of 2 tablets each, with leaflet.