Avivavasc 5/160 mg 28 tablets

Avivavasc 5/160 mg 28 tablets

Composition:

Valsartan 160 mg / Amlodipine 5 mg

Indication:

-Hypertension

Avivavasc (amlodipine and valsartan) is indicated for the treatment of hypertension, to lower blood pressure. 

-Avivavasc may be used in patients whose blood pressure is not adequately controlled on either monotherapy. 

-Avivavasc may also be used as initial therapy in patients who are likely to need multiple drugs to achieve their blood pressure goals.

Dosage and Administration:

Dose once daily. The dosage can be increased after 1 to 2 weeks of therapy to a maximum of one 10/ 320 mg tablet once daily as needed to control blood pressure. 

Avivavasc may be administered with other anti hypertensive agents.

Initial Therapy:

A patient may be initiated on Avivavasc if it is unlikely that control of blood pressure would be achieved with a single agent. The usual starting dose is Avivavasc 5/ 160 mg once daily in patients who are not volume-depleted.

Contraindications:

Do not use in patients with known hypersensitivity to any component.

The concomitant use of Avivavasc with Aliskiren- containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml /min /1.73 m*).

Precautions:

-Fetal Toxicity

Avivavasc can cause fetal harm when administered to a pregnant woman. When pregnancy is detected, discontinue Avivavasc as soon as possible.

-Hypotension:

Treatment with Avivavasc should start under close medical supervision.

-Initiate therapy cautiously in patients with heart failure or recent myocardial infarction and in patients undergoing surgery or dialysis. 

-Risk of Myocardial Infarction or Increased Angina:

Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of amlodipine, particularly in patients with severe obstructive coronary artery disease.

-Hyperkalemia

Drugs that inhibit the rennin-angiotensin system can cause hyperglycemia.

-Avivavasc contains lactose

Side Effects:

Amlodipine:

Gynecomastia has been reported infrequently. 

Jaundice and hepatic enzyme elevations 

Valsartan: 

Hypersensitivity: Angioedema has been reported. 

Digestive: Elevated liver enzymes and reports of hepatitis

Musculoskeletal: Rhabdomyolysis

Renal: Impaired renal function, renal failure 

Dermatologic: Alopecia, bullous dermatitis 

Blood and Lymphatic: Thrombocytopenia 

Vascular: Vasculitis

Storage Method: 

Store at temperature not exceeding 30°C in a dry place.

Package:

Carton box contains 4 strips each of 7 tablets and insert leaflet.